dc.contributor.author | Skarlos, Dimosthenis V. | en |
dc.contributor.author | Aravantinos, Gerasimos | en |
dc.contributor.author | Kosmidis, Paraskevas A. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Gennatas, Constantinos | en |
dc.contributor.author | Beer, M. | en |
dc.contributor.author | Mylonakis, N. | en |
dc.contributor.author | Makrantonakis, P. | en |
dc.contributor.author | Klouvas, G. D. | en |
dc.contributor.author | Karpathios, S. | en |
dc.contributor.author | Linardou, H. | en |
dc.contributor.author | Konstantaras, C. | en |
dc.contributor.author | Fountzilas, George | en |
dc.creator | Skarlos, Dimosthenis V. | en |
dc.creator | Aravantinos, Gerasimos | en |
dc.creator | Kosmidis, Paraskevas A. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Gennatas, Constantinos | en |
dc.creator | Beer, M. | en |
dc.creator | Mylonakis, N. | en |
dc.creator | Makrantonakis, P. | en |
dc.creator | Klouvas, G. D. | en |
dc.creator | Karpathios, S. | en |
dc.creator | Linardou, H. | en |
dc.creator | Konstantaras, C. | en |
dc.creator | Fountzilas, George | en |
dc.date.accessioned | 2018-06-22T09:53:14Z | |
dc.date.available | 2018-06-22T09:53:14Z | |
dc.date.issued | 1996 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41729 | |
dc.description.abstract | We compared, in a multicentric randomised prospective study, the efficacy and toxicity of carboplatin 400 mg/m2 as a single agent (CB) to a combination of carboplatin 300 mg/m2, epirubicin 50 mg/m2 and cyclophosphamide 500 mg/m2 (CB-EC) in advanced ovarian cancer patients. The treatment was scheduled to be administered every 3 weeks for six courses. Following initial laparotomy and cytoreductive surgery, 130 previously untreated patients entered the study. 73 patients were treated with carboplatin alone while 57 received the combination chemotherapy. In the majority of the patients, the regimens had to be given every 4 weeks due to myelosuppression. Nausea, vomiting and alopecia were more severe in the CB-EC arm. Overall, clinical complete response was observed in 73 (56%) and partial response in 20 (15%) patients. The median time to progression was 16.89 months and median survival was 29.54 months. No significant differences in response rate, time to progression, disease-free survival and overall survival were observed between the two treatment arms. The prognostic role of residual disease after initial surgery, complete remission at second-look laparotomy, tumour stage and performance status was confirmed. | en |
dc.language.iso | eng | en |
dc.source | European journal of cancer | en |
dc.subject | Article | en |
dc.subject | Adult | en |
dc.subject | Cyclophosphamide | en |
dc.subject | Human | en |
dc.subject | Aged | en |
dc.subject | Humans | en |
dc.subject | Controlled study | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Carboplatin | en |
dc.subject | Disease progression | en |
dc.subject | Neoplasm staging | en |
dc.subject | Ovarian cancer | en |
dc.subject | Ovarian neoplasms | en |
dc.subject | Priority journal | en |
dc.subject | Prognosis | en |
dc.subject | Alopecia | en |
dc.subject | Anemia | en |
dc.subject | Antineoplastic combined chemotherapy protocols | en |
dc.subject | Bone marrow suppression | en |
dc.subject | Clinical trial | en |
dc.subject | Controlled clinical trial | en |
dc.subject | Disease-free survival | en |
dc.subject | Multicenter study | en |
dc.subject | Ondansetron | en |
dc.subject | Prospective studies | en |
dc.subject | Survival analysis | en |
dc.subject | Dexamethasone | en |
dc.subject | Randomized controlled trial | en |
dc.subject | Survival rate | en |
dc.subject | Epirubicin | en |
dc.subject | Carcinoma | en |
dc.subject | Intravenous drug administration | en |
dc.subject | Vomiting | en |
dc.subject | Nausea | en |
dc.subject | Oral drug administration | en |
dc.subject | Remission induction | en |
dc.subject | Ovary carcinoma | en |
dc.subject | Metoclopramide | en |
dc.subject | Carboplatin-based chemotherapy | en |
dc.title | Carboplatin alone compared with its combination with epirubicin and cyclophosphamide in untreated advanced epithelial ovarian cancer: A hellenic co-operative oncology group study | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/0959-8049(95)00537-4 | |
dc.description.volume | 32 | |
dc.description.issue | 3 | |
dc.description.startingpage | 421 | |
dc.description.endingpage | 428 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Aravantinos, Gerasimos [0000-0002-2106-1713] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-2106-1713 | |