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dc.contributor.authorSypsa, V.en
dc.contributor.authorPsichogiou, M.en
dc.contributor.authorParaskeva, D.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorTsiara, Chrissa G.en
dc.contributor.authorParaskeva, D.en
dc.contributor.authorMicha, Katerinaen
dc.contributor.authorMalliori-Minerva, Melpomenien
dc.contributor.authorPharris, Anastasiaen
dc.contributor.authorWiessing, L.en
dc.contributor.authorDonoghoe, Martinen
dc.contributor.authorFriedman, Samuel R.en
dc.contributor.authorJarlais, Don Desen
dc.contributor.authorDaikos, Georgios L.en
dc.contributor.authorHatzakis, A.en
dc.creatorSypsa, V.en
dc.creatorPsichogiou, M.en
dc.creatorParaskeva, D.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorTsiara, Chrissa G.en
dc.creatorParaskeva, D.en
dc.creatorMicha, Katerinaen
dc.creatorMalliori-Minerva, Melpomenien
dc.creatorPharris, Anastasiaen
dc.creatorWiessing, L.en
dc.creatorDonoghoe, Martinen
dc.creatorFriedman, Samuel R.en
dc.creatorJarlais, Don Desen
dc.creatorDaikos, Georgios L.en
dc.creatorHatzakis, A.en
dc.date.accessioned2018-06-22T09:53:16Z
dc.date.available2018-06-22T09:53:16Z
dc.date.issued2017
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41748
dc.description.abstractBackground. A "seek-test-treat" intervention (ARISTOTLE) was implemented in response to an outbreak of human immunodeficiency virus (HIV) infection among persons who inject drugs (PWID) in Athens. We assess trends in HIV incidence, prevalence, risk behaviors and access to prevention/treatment. Methods. Methods included behavioral data collection, provision of injection equipment, HIV testing, linkage to opioid substitution treatment (OST) programs and HIV care during 5 rounds of respondent-driven sampling (2012-2013). HIV incidence was estimated from observed seroconversions. Results. Estimated coverage of the target population was 88% (71%-100%; 7113 questionnaires/blood samples from 3320 PWID). The prevalence of HIV infection was 16.5%. The incidence per 100 person-years decreased from 7.8 (95% confidence interval, 4.6-13.1) (2012) to 1.7 (0.55-5.31) (2013; P for trend =.001). Risk factors for seroconversion were frequency of injection, homelessness, and history of imprisonment. Injection at least once daily declined from 45.2% to 18.8% (P <.001) and from 36.8% to 26.0% (P =.007) for sharing syringes, and the proportion of undiagnosed HIV infection declined from 84.3% to 15.0% (P <.001). Current OST increased from 12.2% to 27.7% (P <.001), and 48.4% of unlinked seropositive participants were linked to HIV care through 2013. Repeat participants reported higher rates of adequate syringe coverage, linkage to HIV care and OST. Conclusions. Multiple evidence-based interventions delivered through rapid recruitment in a large proportion of the population of PWID are likely to have helped mitigate this HIV outbreak. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.en
dc.language.isoengen
dc.sourceJournal of Infectious Diseasesen
dc.subjectGreeceen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectPriority journalen
dc.subjectIntravenousen
dc.subjectMaleen
dc.subjectRisk factorsen
dc.subjectIncidenceen
dc.subjectComplicationen
dc.subjectDisease outbreaksen
dc.subjectHiv infectionsen
dc.subjectRisk factoren
dc.subjectSexual behavioren
dc.subjectPopulation researchen
dc.subjectPrevalenceen
dc.subjectArticleen
dc.subjectPractice guidelineen
dc.subjectTrend studyen
dc.subjectCohort analysisen
dc.subjectQuestionnaireen
dc.subjectStatistics and numerical dataen
dc.subjectHiven
dc.subjectSubstance abuseen
dc.subjectSubstance abuseen
dc.subjectCohort studiesen
dc.subjectHuman immunodeficiency virus infected patienten
dc.subjectNamed groups of personsen
dc.subjectSeroconversionen
dc.subjectPwiden
dc.subjectHomelessnessen
dc.subjectLongitudinal studyen
dc.subjectCombination prevention.en
dc.subjectHealth programen
dc.subjectOutbreaken
dc.subjectPersons who inject drugen
dc.subjectTestingen
dc.titleRapid Decline in HIV Incidence among Persons Who Inject Drugs during a Fast-Track Combination Prevention Program after an HIV Outbreak in Athensen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/infdis/jix100
dc.description.volume215
dc.description.issue10
dc.description.startingpage1496
dc.description.endingpage1505
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidPsichogiou, M. [0000-0002-3000-8447]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0002-3000-8447


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