dc.contributor.author | Tsiara, Chrissa G. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Dimou, Niki L. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Saroglou, G. | en |
dc.contributor.author | Velonakis, E. | en |
dc.contributor.author | Hatzakis, A. | en |
dc.creator | Tsiara, Chrissa G. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Dimou, Niki L. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Saroglou, G. | en |
dc.creator | Velonakis, E. | en |
dc.creator | Hatzakis, A. | en |
dc.date.accessioned | 2018-06-22T09:53:24Z | |
dc.date.available | 2018-06-22T09:53:24Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41821 | |
dc.description.abstract | Co-infection of human immunodeficiency virus (HIV) with hepatitis C virus (HCV) is rather common. In the era of highly active antiretroviral therapy (HAART), viral hepatitis could result in adverse outcomes in HIV+ patients. The current meta-analysis aims to evaluate the impact of HCV on immunological and virological responses after HAART initiation in HIV/HCV co-infected individuals by synthesizing the existing scientific evidence. A comprehensive search of electronic databases was performed. Eligible studies were analysed using univariate and multivariate meta-analytic methods. Totally, 21 studies involving 22533 individuals were eligible. The estimated summary difference in CD4 cell counts increase between HIV and HIV/HCV co-infected subjects after 3-12 months on HAART was 34.86 cells/mm3 [95% confidence interval (CI): 16.82-52.89]. The difference was more prominent in patients with baseline CD4 counts below 350 cells/mm3 (38.97, 95% CI: 20.00-57.93) and attenuated 2 years later (13.43, 95% CI: 0.83-26.04). The analysis of ratio measures yielded similar findings. The virological control remained unaffected by the presence of HCV (adjusted Hazard Ratio for co-infected patients vs those with HIV alone: 0.99, 95% CI: 0.91-1.07). The bivariate meta-analytic method confirmed the results of the univariate approaches. This meta-analysis supports the adverse effect of HCV on immune recovery of HIV+ patients initiating HAART, especially of those with initially impaired immunologic status. Although this effect diminishes over time, early administration of HAART in the setting of co-infection seems to be justified. © 2013 John Wiley & Sons Ltd. | en |
dc.language.iso | eng | en |
dc.source | Journal of viral hepatitis | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Priority journal | en |
dc.subject | Outcome assessment | en |
dc.subject | Human immunodeficiency virus infection | en |
dc.subject | Meta analysis | en |
dc.subject | Hiv infections | en |
dc.subject | Hepatitis c | en |
dc.subject | Data base | en |
dc.subject | Highly active antiretroviral therapy | en |
dc.subject | Hepatitis c virus | en |
dc.subject | Virology | en |
dc.subject | Viral load | en |
dc.subject | Hiv | en |
dc.subject | Antiretroviral therapy | en |
dc.subject | Highly active | en |
dc.subject | Anti-hiv agents | en |
dc.subject | Antiretrovirus agent | en |
dc.subject | Cd4 lymphocyte count | en |
dc.subject | Hcv | en |
dc.subject | Human immunodeficiency virus infected patient | en |
dc.subject | Antiretroviral treatment | en |
dc.subject | Humoral immunity | en |
dc.subject | Immunological response | en |
dc.subject | Virological response | en |
dc.title | Effect of hepatitis C virus on immunological and virological responses in HIV-infected patients initiating highly active antiretroviral therapy: A meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1111/jvh.12101 | |
dc.description.volume | 20 | |
dc.description.issue | 10 | |
dc.description.startingpage | 715 | |
dc.description.endingpage | 724 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |