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dc.contributor.authorTsiodras, Sotiriosen
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorBonovas, Stefanosen
dc.creatorTsiodras, Sotiriosen
dc.creatorNikolopoulos, Georgios K.en
dc.creatorBonovas, Stefanosen
dc.date.accessioned2018-06-22T09:53:25Z
dc.date.available2018-06-22T09:53:25Z
dc.date.issued2012
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41827
dc.description.abstractCurrent data about the role of adamantanes and neuraminidase inhibitors (NIs) in the chemoprophylaxis against influenza viruses were reviewed. We found significant evidence favouring the role of NIs in the chemoprophylaxis of influenza. Awareness and prudent use are necessary, due to recent evidence of gradually increasing resistance of several influenza strains to these agents. On the other hand, the role of adamantanes appears to have decreased over the last decade. Both pre-pandemic and the novel pandemic A/H1N1 2009 strains exhibited either increasing rates of resistance or no susceptibility to adamantanes. Adamantanes currently only have a theoretical role in influenza chemoprophylaxis given the likelihood of the occurrence of an epidemic due to a susceptible strain. In conclusion, changes in antiviral susceptibility will affect future guidance in prophylaxis against influenza. Further investigation of novel medications with new mechanisms of action is important in this regard. Meanwhile, implementing strategies to conserve our current antivirals is necessary. © 2012 Bentham Science Publishers.en
dc.language.isoengen
dc.sourceCurrent medicinal chemistryen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectHumanen
dc.subjectInfluenzaen
dc.subjectSeasonal influenzaen
dc.subjectMedlineen
dc.subjectDrug blood levelen
dc.subjectDrug half lifeen
dc.subjectInfection risken
dc.subjectInfection preventionen
dc.subjectEnzyme inhibitorsen
dc.subjectAntiviral agentsen
dc.subjectAntivirus agenten
dc.subjectDrug eliminationen
dc.subject2009 h1n1 influenzaen
dc.subjectAntiviral therapyen
dc.subjectDrug metabolismen
dc.subject4 acetamido 5 amino 3 (1 ethylpropoxy) 1 cyclohexene 1 carboxylic aciden
dc.subjectAdamantaneen
dc.subjectAdamantanesen
dc.subjectAmantadineen
dc.subjectAntiviralsen
dc.subjectChemoprophylaxisen
dc.subjectEnzyme inhibitionen
dc.subjectLaninamivir octanoateen
dc.subjectNeuraminidaseen
dc.subjectNeuraminidase inhibitorsen
dc.subjectOrthomyxoviridaeen
dc.subjectOseltamiviren
dc.subjectPeramiviren
dc.subjectRimantadineen
dc.subjectZanamiviren
dc.titleAntivirals used for influenza chemoprophylaxisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.2174/092986712804485953
dc.description.volume19
dc.description.issue35
dc.description.startingpage5947
dc.description.endingpage5956
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBonovas, Stefanos [0000-0001-6102-6579]
dc.contributor.orcidTsiodras, Sotirios [0000-0002-0463-4321]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0001-6102-6579
dc.gnosis.orcid0000-0002-0463-4321


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