dc.contributor.author | Varnavidou-Nicolaidou, Agathi | en |
dc.contributor.author | Karpasitou, Katerina | en |
dc.contributor.author | Georgiou, Dora | en |
dc.contributor.author | Stylianou, Galatia | en |
dc.contributor.author | Kokkofitou, Avgousta | en |
dc.contributor.author | Christodoulides, Michalis | en |
dc.contributor.author | Constantinou, Constantina | en |
dc.contributor.author | Gregoriadou, Christiana | en |
dc.contributor.author | Kyriakides, George K. | en |
dc.creator | Varnavidou-Nicolaidou, Agathi | en |
dc.creator | Karpasitou, Katerina | en |
dc.creator | Georgiou, Dora | en |
dc.creator | Stylianou, Galatia | en |
dc.creator | Kokkofitou, Avgousta | en |
dc.creator | Christodoulides, Michalis | en |
dc.creator | Constantinou, Constantina | en |
dc.creator | Gregoriadou, Christiana | en |
dc.creator | Kyriakides, George K. | en |
dc.date.accessioned | 2018-06-22T09:53:25Z | |
dc.date.available | 2018-06-22T09:53:25Z | |
dc.date.issued | 2004 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41829 | |
dc.description.abstract | The major purpose of the present study was to investigate the frequency of human leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with ankylosing spondylitis (AS) and other HLA-B27-related diseases in the Greek Cypriot population. We selected 102 HLA-B27-positive individuals (60 controls and 42 patients). Typing of the HLA-B27 alleles was performed by polymerase chain reaction amplification with sequence-specific primers. Only two alleles were detected in the patient group: B*2702 (n = 31, 73.8%) and B*2705 (n = 11, 26.2%). The HLA-B*2707 allele was detected (n = 10, 16.7%) only in the healthy controls in addition to the B*2702 (n = 31, 51.7%) and B*2705 (n = 19, 31.7%) alleles. Our results show a restricted number of HLA-B27 subtypes associated with AS and other B27-related diseases and an elevated frequency of the B*2702 allele in the AS patients. The allele B*2707 seems to have a protective role in the population studied because it was found only in the healthy controls. © American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc. | en |
dc.language.iso | eng | en |
dc.source | Human immunology | en |
dc.subject | Ankylosing spondylitis | en |
dc.subject | Hla-b27 subtypes | en |
dc.subject | Protective allele | en |
dc.title | HLA-B27 in the Greek Cypriot population: Distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707 | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.humimm.2004.08.177 | |
dc.description.volume | 65 | |
dc.description.issue | 12 | |
dc.description.startingpage | 1451 | |
dc.description.endingpage | 1454 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |