dc.contributor.author | Waddell, T. | en |
dc.contributor.author | Kotsori, A. | en |
dc.contributor.author | Constantinidou, Anastasia | en |
dc.contributor.author | Yousaf, N. | en |
dc.contributor.author | Ashley, Sue | en |
dc.contributor.author | Parton, M. | en |
dc.contributor.author | Allen, M. | en |
dc.contributor.author | Starling, N. | en |
dc.contributor.author | Papadopoulos, P. | en |
dc.contributor.author | O'Brien, M. | en |
dc.contributor.author | Smith, I. E. | en |
dc.contributor.author | Johnston, S. L. | en |
dc.creator | Waddell, T. | en |
dc.creator | Kotsori, A. | en |
dc.creator | Constantinidou, Anastasia | en |
dc.creator | Yousaf, N. | en |
dc.creator | Ashley, Sue | en |
dc.creator | Parton, M. | en |
dc.creator | Allen, M. | en |
dc.creator | Starling, N. | en |
dc.creator | Papadopoulos, P. | en |
dc.creator | O'Brien, M. | en |
dc.creator | Smith, I. E. | en |
dc.creator | Johnston, S. L. | en |
dc.date.accessioned | 2018-06-22T09:53:26Z | |
dc.date.available | 2018-06-22T09:53:26Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41839 | |
dc.description.abstract | BACKGROUND: Recent UK clinical guidance advises against continuing trastuzumab (T) beyond disease progression (PD) in the absence of brain metastases in patients with HER-2 positive (+ ve) advanced breast cancer. We have retrospectively evaluated the outcome of patients with HER-2 + ve locally advanced (LA) or metastatic breast cancer (MBC) who continued T beyond PD, treated in our unit. METHODS: All HER-2+ ve patients on our prospectively maintained database with LA or MBC who received T beyond PD after adjuvant or one line of T for advanced disease were assessed for response and outcome. From the timepoint of T continuation beyond PD, we calculated the overall disease control rate, time to progression (TTP), and overall survival (OS). RESULTS: One hundred and fourteen patients with HER-2 + ve LA or MBC treated with T beyond PD were identified. The main site of disease was visceral in 84 (74%) patients. Seventy-six (66%) had one line of chemotherapy before continuation of T beyond PD and 21 (19%) had two or more. Post-progression, 66 (58%) received T combined with chemotherapy. Of the 93 (82%) patients with documented clinical or radiological response evaluation, 67 (59%) were considered as having stable disease or better. The median TTP was 24 weeks (95% CI: 21-28) and the median OS was 19 months (95% CI: 12-24). CONCLUSION: Our results from an unselected group of patients provide additional evidence that continuation of T beyond PD is of clinical benefit. © 2011 Cancer Research UK. | en |
dc.language.iso | eng | en |
dc.source | British journal of cancer | en |
dc.subject | Metastatic breast cancer | en |
dc.subject | Trastuzumab | en |
dc.subject | Her2 positive | en |
dc.title | Trastuzumab beyond progression in HER2-positive advanced breast cancer: The Royal Marsden experience | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/bjc.2011.138 | |
dc.description.volume | 104 | |
dc.description.issue | 11 | |
dc.description.startingpage | 1675 | |
dc.description.endingpage | 1679 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Constantinidou, Anastasia [0000-0001-5316-7574] | |
dc.gnosis.orcid | 0000-0001-5316-7574 | |