dc.contributor.author | Iliadis, Charalambos | en |
dc.contributor.author | Apostolopoulos, D. J. | en |
dc.contributor.author | Papadopoulos, G. | en |
dc.contributor.author | Tzortzidis, F. | en |
dc.contributor.author | Wozniak, Greta | en |
dc.contributor.author | Georgoulias, Panagiotis | en |
dc.contributor.author | Kunz, A. | en |
dc.contributor.author | Panagiotopoulos, V. | en |
dc.contributor.author | Maraziotis, T. | en |
dc.contributor.author | Vassilakos, P. J. | en |
dc.creator | Iliadis, Charalambos | en |
dc.creator | Apostolopoulos, D. J. | en |
dc.creator | Papadopoulos, G. | en |
dc.creator | Tzortzidis, F. | en |
dc.creator | Wozniak, Greta | en |
dc.creator | Georgoulias, Panagiotis | en |
dc.creator | Kunz, A. | en |
dc.creator | Panagiotopoulos, V. | en |
dc.creator | Maraziotis, T. | en |
dc.creator | Vassilakos, P. J. | en |
dc.date.accessioned | 2018-06-22T09:53:40Z | |
dc.date.available | 2018-06-22T09:53:40Z | |
dc.date.issued | 2006 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41962 | |
dc.description.abstract | Aim: To estimate the association between single photon emission computed tomography (SPECT) imaging and neuro-specific enolase (NSE) serum level measurement in patients with subarachnoid haemorrhage (SAH) and also to present our experience in using these data for patient evaluation. Material and method: Thirty-five patients (18 female and 17 male, mean age 57.5 ± 11.9 y) with clinical findings of vasospasm after SAH underwent 99mTC-ECD SPECT imaging. In 23 out of the 35 patients, serum levels of NSE were assessed on admission. Brain perfusion was measured semi-quantitatively using symmetrical regions of interest, automatically drawn over cortical and subcortical structures on consecutive transverse slices. A summed perfusion defect score (SPDS) was used to' quantify the brain perfusion. Statistical analysis was carried out using the Kruskal-Wallis test, Mann-Whitney U test and ROC analysis, as appropriate. Results: Eighteen patients had abnormal SPECT studies. The patients were divided into three groups according to NSE levels. Group I comprised 13 patients with NSE values = 15 ng/ml, group II comprised 7 patients with 15 ng/ml <NSE < 19 ng/ml, and group III comprised 3 patients with NSE = 19 ng/ml. SPECT/SPDS data and NSE levels of groups II and I were positively linearly correlated (Spearman's coeff = 0.71, p<0.05), while group III clearly defines a separate population. The linear correlation between SPECT/SPDS and NSE was statistically significant (p<0.05). Very high NSE values were noticed in three patients who eventually died. Conclusion: Both SPECT abnormalities and high serum NSE concentration are potentially helpful in the evaluation of patients with SAH. ©Borgis. | en |
dc.language.iso | eng | en |
dc.source | New Medicine | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Prognosis | en |
dc.subject | Quantitative analysis | en |
dc.subject | Clinical article | en |
dc.subject | Adolescent | en |
dc.subject | Male | en |
dc.subject | Sensitivity and specificity | en |
dc.subject | Single photon emission computer tomography | en |
dc.subject | Brain perfusion | en |
dc.subject | Brain vasospasm | en |
dc.subject | Cysteine ethyl ester tc 99m | en |
dc.subject | Glasgow outcome scale | en |
dc.subject | Subarachnoid hemorrhage | en |
dc.subject | 99mtc-ecd spect | en |
dc.subject | Cerebral blood flow (cbf) | en |
dc.subject | Glasgow coma scale | en |
dc.subject | Neuro-specific enolase (nse) | en |
dc.subject | Neuron specific enolase | en |
dc.subject | Patient assessment | en |
dc.subject | Subarachnoid haemorrhage (sah) | en |
dc.title | Brain perfusion SPECT with 99mTC-ECD and serum neuron-specific enolase in patients with spontaneous subarachnoid haemorrhage and clinical vasospasm | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 9 | |
dc.description.issue | 4 | |
dc.description.startingpage | 90 | |
dc.description.endingpage | 96 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Wozniak, Greta [0000-0002-8939-0927] | |
dc.contributor.orcid | Georgoulias, Panagiotis [0000-0002-6493-705X] | |
dc.gnosis.orcid | 0000-0002-8939-0927 | |
dc.gnosis.orcid | 0000-0002-6493-705X | |