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dc.contributor.authorKalogera-Fountzila, Annaen
dc.contributor.authorKosmidis, Paraskevas A.en
dc.contributor.authorBacoyiannis, Charalambosen
dc.contributor.authorNicolaou, A.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorBriassoulis, E. Chen
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorSkarlos, Dimosthenis V.en
dc.contributor.authorDaniilidis, J.en
dc.contributor.authorFountzilas, Georgeen
dc.creatorKalogera-Fountzila, Annaen
dc.creatorKosmidis, Paraskevas A.en
dc.creatorBacoyiannis, Charalambosen
dc.creatorNicolaou, A.en
dc.creatorSamantas, E.en
dc.creatorBriassoulis, E. Chen
dc.creatorPavlidis, Nicholasen
dc.creatorSkarlos, Dimosthenis V.en
dc.creatorDaniilidis, J.en
dc.creatorFountzilas, Georgeen
dc.date.accessioned2018-06-22T09:53:43Z
dc.date.available2018-06-22T09:53:43Z
dc.date.issued1998
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41989
dc.description.abstractThe identification of prognostic factors influencing local control and survival of patients with nasopharyngeal cancer (NPC) might help in pointing out those patients who would probably benefit from primary treatment. A series of 137 Greek patients with locally advanced NPC treated with chemotherapy and/or radiation were analyzed for significant prognostic factors influencing complete response (CR) to treatment, time to progression (TTP) and overall survival (OS). After the completion of treatment, 92 (67%) patients achieved CR. Logistic regression analysis revealed that only T classification was significant for CR (p = 0.0058). After a median follow-up of 5 years, 66 (48%) patients demonstrated tumor progression and 64 (47%) died. Median TTP was 25.8 months (range, 0.3-118+) and median survival 58.3 months (range, 0.3-124+). Cox proportional hazards model identified age (p = 0.024) and T classification (p = 0.009) as significant factors for TTP. These two factors were also found to be significant for OS (p = 0.005 and p = 0.013, respectively). The present study has shown that major prognostic factors influencing the outcome of our patients with NPC are similar to those reported in recent Chinese studies. These prognostic factors may be used as stratification factors in randomized clinical trials.en
dc.language.isoengen
dc.sourceAnticancer Researchen
dc.subjectRegression analysisen
dc.subjectAgeen
dc.subjectAge factorsen
dc.subjectArticleen
dc.subjectBleomycinen
dc.subjectCancer chemotherapyen
dc.subjectCisplatinen
dc.subjectFluorouracilen
dc.subjectHumanen
dc.subjectHydroxyureaen
dc.subjectMethotrexateen
dc.subjectMitomycinen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectCancer growthen
dc.subjectCancer survivalen
dc.subjectCarboplatinen
dc.subjectChemotherapyen
dc.subjectFollow upen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectRetrospective studiesen
dc.subjectClinical trialen
dc.subjectTreatment outcomeen
dc.subjectRandomized controlled trialen
dc.subjectTime factorsen
dc.subjectAdolescenten
dc.subjectCancer radiotherapyen
dc.subjectFolinic aciden
dc.subjectMaleen
dc.subjectRadiotherapyen
dc.subjectCancer classificationen
dc.subjectNasopharynx canceren
dc.subjectHead and neck canceren
dc.subjectNasopharyngeal canceren
dc.subjectNasopharyngeal neoplasmsen
dc.subjectPatient selectionen
dc.titlePrognostic factors influencing complete response to treatment and survival of patients with nasopharyngeal canceren
dc.typeinfo:eu-repo/semantics/article
dc.description.volume18
dc.description.issue1 Ben
dc.description.startingpage587
dc.description.endingpage593
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidKalogera-Fountzila, Anna [0000-0002-6801-3129]
dc.gnosis.orcid0000-0002-2195-9961|0000-0002-6801-3129


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