Single agent activity of rhizoxin in non-small-cell lung cancer: A phase II trial of the EORTC early clinical trials group
dc.contributor.author | Kaplan, S. | en |
dc.contributor.author | Hanauske, A. R. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Bruntsch, U. | en |
dc.contributor.author | Velde, A. Te | en |
dc.contributor.author | Wanders, J. | en |
dc.contributor.author | Heinrich, B. | en |
dc.contributor.author | Verweij, J. | en |
dc.creator | Kaplan, S. | en |
dc.creator | Hanauske, A. R. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Bruntsch, U. | en |
dc.creator | Velde, A. Te | en |
dc.creator | Wanders, J. | en |
dc.creator | Heinrich, B. | en |
dc.creator | Verweij, J. | en |
dc.date.accessioned | 2018-06-22T09:53:44Z | |
dc.date.available | 2018-06-22T09:53:44Z | |
dc.date.issued | 1996 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41994 | |
dc.description.abstract | In a multicentre trial of the EORTC-Early Clinical Trials Group (ECTG) we treated 31 chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC) with rhizoxin, a novel tubulin-binding agent. The drug was given as an i.v. bolus injection at 2 mg m-2 once every 3 weeks in an outpatient setting. Prophylactic antiemetics were not routinely given. Of the 29 eligible patients, nine had been treated surgically and three had received radiotherapy. The main toxic effects observed were stomatitis (34% of cycles) and neutropenia (41% of cycles). Neutropenic fever was rare (3% of cycles). Twenty-seven patients were evaluable for response. There were four partial responses (15%), while 13 patients (48%) showed stabilisation of their disease. The median duration of response was 7 months (range 6.0-10.7 months) and median survival from the start of rhizoxin treatment was 6 months (range 2-14.7 months). Rhizoxin as single agent shows activity in patients with advanced NSCLC. | en |
dc.language.iso | eng | en |
dc.source | British journal of cancer | en |
dc.subject | Article | en |
dc.subject | Antineoplastic agent | en |
dc.subject | Cancer chemotherapy | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Middle aged | en |
dc.subject | Cancer survival | en |
dc.subject | Priority journal | en |
dc.subject | Alopecia | en |
dc.subject | Anemia | en |
dc.subject | Clinical article | en |
dc.subject | Clinical trial | en |
dc.subject | Diarrhea | en |
dc.subject | Leukopenia | en |
dc.subject | Multicenter study | en |
dc.subject | Neutropenia | en |
dc.subject | Phase 2 clinical trial | en |
dc.subject | Stomatitis | en |
dc.subject | Thrombocytopenia | en |
dc.subject | Antineoplastic activity | en |
dc.subject | Drug hypersensitivity | en |
dc.subject | Fever | en |
dc.subject | Lung neoplasms | en |
dc.subject | Lung non small cell cancer | en |
dc.subject | Carcinoma | en |
dc.subject | Malaise | en |
dc.subject | Male | en |
dc.subject | Intravenous drug administration | en |
dc.subject | Vomiting | en |
dc.subject | Blood toxicity | en |
dc.subject | Nausea | en |
dc.subject | Antineoplastic | en |
dc.subject | Phase ii | en |
dc.subject | Skin toxicity | en |
dc.subject | Headache | en |
dc.subject | Non-small-cell lung | en |
dc.subject | Outpatient | en |
dc.subject | Antibiotics | en |
dc.subject | Non-small-cell lung cancer | en |
dc.subject | Hematopoiesis | en |
dc.subject | Lactones | en |
dc.subject | Macrolides | en |
dc.subject | Rhizoxin | en |
dc.subject | Phlebitis | en |
dc.title | Single agent activity of rhizoxin in non-small-cell lung cancer: A phase II trial of the EORTC early clinical trials group | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 73 | |
dc.description.issue | 3 | |
dc.description.startingpage | 403 | |
dc.description.endingpage | 405 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 |
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