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dc.contributor.authorNoel, J.en
dc.contributor.authorRabinovitch, A.en
dc.contributor.authorOlson, L.en
dc.contributor.authorKyriakides, George K.en
dc.contributor.authorMiller, Jody C.en
dc.contributor.authorMintz, D. H.en
dc.creatorNoel, J.en
dc.creatorRabinovitch, A.en
dc.creatorOlson, L.en
dc.creatorKyriakides, George K.en
dc.creatorMiller, Jody C.en
dc.creatorMintz, D. H.en
dc.date.accessioned2018-06-22T09:54:05Z
dc.date.available2018-06-22T09:54:05Z
dc.date.issued1982
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42188
dc.description.abstractA modified collagenase digestion method is described for the isolation of large numbers of islets from the canine pancreas ( 3500 islets/g). The islets isolated by this technique remained viable and released insulin in response to secretagogues after one week of maintenance in tissue culture. Islets isolated from a single donor pancreas were re-implanted into the spleen of the same animal made diabetic by subtotal pancreatectomy and two injections of streptozotocin. Hyperglycemia was corrected in two dogs and decreased in a third dog followed for 30 days. The islet isolation method described, therefore, provides a sufficiently large yield of viable islets from one donor pancreas to correct or improve diabetes in a recipient animal. © 1982.en
dc.language.isoengen
dc.sourceMetabolismen
dc.titleA method for large-scale, high-yield isolation of canine pancreatic islets of Langerhansen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/0026-0495(82)90133-0
dc.description.volume31
dc.description.issue2
dc.description.startingpage184
dc.description.endingpage187
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


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