dc.contributor.author | Noel, J. | en |
dc.contributor.author | Rabinovitch, A. | en |
dc.contributor.author | Olson, L. | en |
dc.contributor.author | Kyriakides, George K. | en |
dc.contributor.author | Miller, Jody C. | en |
dc.contributor.author | Mintz, D. H. | en |
dc.creator | Noel, J. | en |
dc.creator | Rabinovitch, A. | en |
dc.creator | Olson, L. | en |
dc.creator | Kyriakides, George K. | en |
dc.creator | Miller, Jody C. | en |
dc.creator | Mintz, D. H. | en |
dc.date.accessioned | 2018-06-22T09:54:05Z | |
dc.date.available | 2018-06-22T09:54:05Z | |
dc.date.issued | 1982 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42188 | |
dc.description.abstract | A modified collagenase digestion method is described for the isolation of large numbers of islets from the canine pancreas ( 3500 islets/g). The islets isolated by this technique remained viable and released insulin in response to secretagogues after one week of maintenance in tissue culture. Islets isolated from a single donor pancreas were re-implanted into the spleen of the same animal made diabetic by subtotal pancreatectomy and two injections of streptozotocin. Hyperglycemia was corrected in two dogs and decreased in a third dog followed for 30 days. The islet isolation method described, therefore, provides a sufficiently large yield of viable islets from one donor pancreas to correct or improve diabetes in a recipient animal. © 1982. | en |
dc.language.iso | eng | en |
dc.source | Metabolism | en |
dc.title | A method for large-scale, high-yield isolation of canine pancreatic islets of Langerhans | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/0026-0495(82)90133-0 | |
dc.description.volume | 31 | |
dc.description.issue | 2 | |
dc.description.startingpage | 184 | |
dc.description.endingpage | 187 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |