Show simple item record

Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: A Hellenic Cooperative Oncology Group study

dc.contributor.authorNikitas, N.en
dc.contributor.authorKaradimou, A.en
dc.contributor.authorTsitoura, E.en
dc.contributor.authorSoupos, N.en
dc.contributor.authorTsiatas, M.en
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorPectasides, Dimitriosen
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorChrisofos, M.en
dc.contributor.authorAdamakis, I.en
dc.contributor.authorMurray, S.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorDimopoulos, M. A.en
dc.contributor.authorBamias, A. T.en
dc.creatorNikitas, N.en
dc.creatorKaradimou, A.en
dc.creatorTsitoura, E.en
dc.creatorSoupos, N.en
dc.creatorTsiatas, M.en
dc.creatorKaravasilis, V.en
dc.creatorPectasides, Dimitriosen
dc.creatorPavlidis, Nicholasen
dc.creatorChrisofos, M.en
dc.creatorAdamakis, I.en
dc.creatorMurray, S.en
dc.creatorFountzilas, Georgeen
dc.creatorDimopoulos, M. A.en
dc.creatorBamias, A. T.en
dc.date.accessioned2018-06-22T09:54:05Z
dc.date.available2018-06-22T09:54:05Z
dc.date.issued2012
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42190
dc.description.abstractAim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T and 8092C>A polymorphisms was determined by PCR amplification and RFLP in 113 advanced UC patients, treated with platinum-based chemotherapy. Results: Seventy eight patients (69%) were carriers of the 19007T polymorphic allele: 51 (45%) heterozygotes and 27 (24%) homozygotes. Fifty three (47%) patients were carriers of the 8092A polymorphic allele: the frequencies of C/A and A/A genotypes were 37% and 10%, respectively. The T/T genotype was independently associated with prolonged median cancer-specific survival (not-reached vs 14.8 months; p = 0.026). There was no interaction between T/T or any other genotype with the type of platinum derivative (cisplatin/carboplatin). Conclusion: 19007C>T, especially in its homozygotic state, but not 8092C>A polymorphism, could be a useful prognostic marker in advanced UC treated with platinum-based chemotherapy. Original submitted 17 July 2012; Revision submitted 21 September 201. © 2012 Future Medicine Ltd.en
dc.language.isoengen
dc.sourcePharmacogenomicsen
dc.subjectArticleen
dc.subjectCancer chemotherapyen
dc.subjectCisplatinen
dc.subjectDoxorubicinen
dc.subjectHumanen
dc.subjectMethotrexateen
dc.subjectVinblastineen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCancer patienten
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectAdvanced canceren
dc.subjectCarboplatinen
dc.subjectDrug responseen
dc.subjectNeoplasm stagingen
dc.subjectPlatinum derivativeen
dc.subjectDisease-free survivalen
dc.subjectGemcitabineen
dc.subjectTreatment outcomeen
dc.subjectCancer prognosisen
dc.subjectMaleen
dc.subjectGenetic associationen
dc.subjectSingle nucleotide polymorphismen
dc.subjectGene frequencyen
dc.subjectGenotypeen
dc.subjectPolymorphismen
dc.subjectSingle nucleotideen
dc.subjectSurvival timeen
dc.subjectUrogenital tract canceren
dc.subjectKaplan-meier estimateen
dc.subjectDnaen
dc.subjectGene amplificationen
dc.subjectPolymerase chain reactionen
dc.subjectMessenger rnaen
dc.subjectProgression free survivalen
dc.subjectDna-binding proteinsen
dc.subjectGenetic analysisen
dc.subjectHeterozygoteen
dc.subjectHomozygoteen
dc.subjectPlatinumen
dc.subjectUrologic neoplasmsen
dc.subjectRestriction fragment length polymorphismen
dc.subjectBiomarkersen
dc.subjectCancer specific survivalen
dc.subjectDose densificationen
dc.subjectEndonucleasesen
dc.subjectErcc1 geneen
dc.subjectExcision repair cross complementing protein 1en
dc.subjectGenetic association studiesen
dc.subjectHuman ercc1 geneen
dc.subjectNucleotide excision repairen
dc.subjectPharmacogeneticsen
dc.subjectPharmacologicalen
dc.subjectSingle-nucleotide polymorphismen
dc.subjectUrothelial canceren
dc.titleAssociation of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: A Hellenic Cooperative Oncology Group studyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.2217/pgs.12.162
dc.description.volume13
dc.description.issue14
dc.description.startingpage1595
dc.description.endingpage1607
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidKaravasilis, V. [0000-0002-5806-9399]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-5806-9399


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record