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dc.contributor.authorPapaconstantinou, Ioannisen
dc.contributor.authorZeglinas, C.en
dc.contributor.authorGazouli, Mariaen
dc.contributor.authorNastos, Constantinosen
dc.contributor.authorYiallourou, Anneza I.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorTzathas, C.en
dc.creatorPapaconstantinou, Ioannisen
dc.creatorZeglinas, C.en
dc.creatorGazouli, Mariaen
dc.creatorNastos, Constantinosen
dc.creatorYiallourou, Anneza I.en
dc.creatorPapalois, A.en
dc.creatorTzathas, C.en
dc.date.accessioned2018-06-22T09:54:08Z
dc.date.available2018-06-22T09:54:08Z
dc.date.issued2014
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42208
dc.description.abstractIntroduction: Tumor necrosis factor (TNF)a is a cytokine exerting pleiotropic effects on critical cell functions and, most importantly, is the main regulator of pro-inflammatory cytokine production and a key player in the pathophysiology of numerous autoimmune diseases, including Crohn's disease. Methods: TNFa became a therapeutic target and TNFa blocking agents are currently used in the treatment of inflammatory diseases. Beyond the therapeutic benefits deriving from TNFa neutralization, amendments in the cellular functions of the immune system may as well induce potent immunosuppressive effects. An attenuated immune response may compromise the intestinal healing ability, thus leading to weaker anastomosis and increased risk of anastomotic leak and septic complications. Results: This hypothesis raises great concerns about the safety of perioperative administration of anti-TNF and has been the endpoint of numerous studies. Conclusion: The aim of this review is to critically evaluate the evidence regarding the role of TNFa in anastomosis related complications after abdominal surgery in Crohn's disease patients. © 2014 The Society for Surgery of the Alimentary Tract.en
dc.language.isoengen
dc.sourceJournal of Gastrointestinal Surgeryen
dc.subjectWound healingen
dc.subjectIntestinal anastomosesen
dc.subjectPostoperative complicationsen
dc.subjectTnfaen
dc.titleThe Impact of Peri-operative Anti-TNF Treatment on Anastomosis-Related Complications in Crohn's Disease Patients. A Critical Reviewen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s11605-014-2487-3
dc.description.volume18
dc.description.issue6
dc.description.startingpage1216
dc.description.endingpage1224
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidYiallourou, Anneza I. [0000-0003-1237-1661]
dc.contributor.orcidPapaconstantinou, Ioannis [0000-0002-4614-9041]
dc.contributor.orcidNastos, Constantinos [0000-0001-5960-6494]
dc.contributor.orcidGazouli, Maria [0000-0002-3295-6811]
dc.gnosis.orcid0000-0003-1237-1661
dc.gnosis.orcid0000-0002-4614-9041
dc.gnosis.orcid0000-0001-5960-6494
dc.gnosis.orcid0000-0002-3295-6811


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