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dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorNikolaides, C.en
dc.contributor.authorKlouvas, G. D.en
dc.contributor.authorBriassoulis, E. Chen
dc.creatorPavlidis, Nicholasen
dc.creatorNikolaides, C.en
dc.creatorKlouvas, G. D.en
dc.creatorBriassoulis, E. Chen
dc.date.accessioned2018-06-22T09:54:17Z
dc.date.available2018-06-22T09:54:17Z
dc.date.issued1994
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42280
dc.description.abstractThe main purpose of this trial was to investigate the activity of a less toxic regimen in patients with advanced gastric carcinoma regarding response rate and survival. We report on a pilot study of 20 patients treated with the combination of 5-fluorouracil and folinic acid. 5-fluorouracil administered at a daily dose of 450 mg/m2 followed by folinic acid 200 mg/m2 for four consecutive days every four weeks. The overall response rate was 15% with one complete and two partial responders. The median duration of response was 11, 10 and 10 months respectively. The median survival of all patients was 9 months. Toxicity was mild and consisted primarily of diarrhea. Stomatitis and myelosuppression occurred rarely. In conclusion, the combination of 5-fluorouracil and folinic acid has moderate activity in gastric cancer, while median survival appears similar to the other more intensive regimens. The combination is very well tolerated with minimal toxicity. A detailed review of the literature regarding the effectiveness of the above regimens on response rate, overall survival and toxicity is also presented.en
dc.language.isoengen
dc.sourceJournal of Chemotherapyen
dc.subjectArticleen
dc.subjectCancer chemotherapyen
dc.subjectCisplatinen
dc.subjectDoxorubicinen
dc.subjectEtoposideen
dc.subjectFluorouracilen
dc.subjectHumanen
dc.subjectHydroxyureaen
dc.subjectAdenocarcinomaen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectAntineoplastic combined chemotherapy protocolsen
dc.subjectBone marrow suppressionen
dc.subjectClinical articleen
dc.subjectDiarrheaen
dc.subjectDrug efficacyen
dc.subjectNeutropeniaen
dc.subjectStomatitisen
dc.subjectAlpha interferonen
dc.subjectEpirubicinen
dc.subjectMaleen
dc.subjectGastric canceren
dc.subjectStomach carcinomaen
dc.subjectStomach neoplasmsen
dc.subjectLeucovorinen
dc.subjectDrug toleranceen
dc.subjectMitomycin cen
dc.subjectPilot projectsen
dc.subjectMiddle ageen
dc.subject5-fluorouracilen
dc.subjectComparative studyen
dc.subjectFolinic aciden
dc.titleIs the combination of 5-fluorouracil and folinic acid effective in advanced gastric carcinoma? Results of a pilot study and review of the literatureen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume6
dc.description.issue6
dc.description.startingpage417
dc.description.endingpage422
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


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