dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Nikolaides, C. | en |
dc.contributor.author | Klouvas, G. D. | en |
dc.contributor.author | Briassoulis, E. Ch | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Nikolaides, C. | en |
dc.creator | Klouvas, G. D. | en |
dc.creator | Briassoulis, E. Ch | en |
dc.date.accessioned | 2018-06-22T09:54:17Z | |
dc.date.available | 2018-06-22T09:54:17Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42280 | |
dc.description.abstract | The main purpose of this trial was to investigate the activity of a less toxic regimen in patients with advanced gastric carcinoma regarding response rate and survival. We report on a pilot study of 20 patients treated with the combination of 5-fluorouracil and folinic acid. 5-fluorouracil administered at a daily dose of 450 mg/m2 followed by folinic acid 200 mg/m2 for four consecutive days every four weeks. The overall response rate was 15% with one complete and two partial responders. The median duration of response was 11, 10 and 10 months respectively. The median survival of all patients was 9 months. Toxicity was mild and consisted primarily of diarrhea. Stomatitis and myelosuppression occurred rarely. In conclusion, the combination of 5-fluorouracil and folinic acid has moderate activity in gastric cancer, while median survival appears similar to the other more intensive regimens. The combination is very well tolerated with minimal toxicity. A detailed review of the literature regarding the effectiveness of the above regimens on response rate, overall survival and toxicity is also presented. | en |
dc.language.iso | eng | en |
dc.source | Journal of Chemotherapy | en |
dc.subject | Article | en |
dc.subject | Cancer chemotherapy | en |
dc.subject | Cisplatin | en |
dc.subject | Doxorubicin | en |
dc.subject | Etoposide | en |
dc.subject | Fluorouracil | en |
dc.subject | Human | en |
dc.subject | Hydroxyurea | en |
dc.subject | Adenocarcinoma | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Antineoplastic combined chemotherapy protocols | en |
dc.subject | Bone marrow suppression | en |
dc.subject | Clinical article | en |
dc.subject | Diarrhea | en |
dc.subject | Drug efficacy | en |
dc.subject | Neutropenia | en |
dc.subject | Stomatitis | en |
dc.subject | Alpha interferon | en |
dc.subject | Epirubicin | en |
dc.subject | Male | en |
dc.subject | Gastric cancer | en |
dc.subject | Stomach carcinoma | en |
dc.subject | Stomach neoplasms | en |
dc.subject | Leucovorin | en |
dc.subject | Drug tolerance | en |
dc.subject | Mitomycin c | en |
dc.subject | Pilot projects | en |
dc.subject | Middle age | en |
dc.subject | 5-fluorouracil | en |
dc.subject | Comparative study | en |
dc.subject | Folinic acid | en |
dc.title | Is the combination of 5-fluorouracil and folinic acid effective in advanced gastric carcinoma? Results of a pilot study and review of the literature | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 6 | |
dc.description.issue | 6 | |
dc.description.startingpage | 417 | |
dc.description.endingpage | 422 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |