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dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorSchultz, R. M.en
dc.contributor.authorChirigos, M. A.en
dc.contributor.authorLuetzeler, J.en
dc.creatorPavlidis, Nicholasen
dc.creatorSchultz, R. M.en
dc.creatorChirigos, M. A.en
dc.creatorLuetzeler, J.en
dc.date.accessioned2018-06-22T09:54:22Z
dc.date.available2018-06-22T09:54:22Z
dc.date.issued1978
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42326
dc.description.abstractPyran copolymer (NSC-46015) was compared with five maleic anhydride-divinyl ether copolymers (MVEs) of narrow molecular weight range both for the ability to render macrophages nonspecifically tumoricidal and to retard the development of artificially induced metastases. All MVEs were found effective at activating macrophages in vivo, although the optimal dose for each varied. No correlation was obtained between intrinsic viscosity and degree of activation. Pyran was found to strikingly inhibit M109 pulmonary metastases formation when given over a period of 5 days prior to, or 1 day after, iv tumor inoculation. Histologically, tumor inhibition appeared to result from macrophage accumulations and histiocytic granulomas in the lung. Generally, when MVEs were compared in the artificial metastasis model, polymers with the lower molecular weights were the most active.en
dc.language.isoengen
dc.sourceCancer treatment reportsen
dc.subjectMaleen
dc.subjectNeoplasmsen
dc.subjectLung neoplasmsen
dc.subjectNeoplasm metastasisen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectAnimalen
dc.subjectDisease modelsen
dc.subjectImmunologicen
dc.subjectInbred balb cen
dc.subjectPolymersen
dc.subjectCytotoxicityen
dc.subjectExperimentalen
dc.subjectMacrophagesen
dc.subjectMolecular weighten
dc.subjectPyran copolymeren
dc.titleEffect of maleic anhydride-divinyl ether copolymers on experimental M109 metastases and macrophage tumoricidal functionen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume62
dc.description.issue11
dc.description.startingpage1817
dc.description.endingpage1822
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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