• Conference Object  

      Biphasic, structure-based modeling of tissue equivalent mechanics 

      Barocas, V. Η; Chandran, P. L.; Stylianopoulos, T. (Affiliation: Department of Bioengineering, University of California, Berkeley, CA 94720, United StatesAffiliation: Department of Chemical Engineering, University of Minnesota, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, MN 55455, United StatesCorrespondence Address: Chandran, P.L.Department of Bioengineering, University of California, Berkeley, CA 94720, United States, 2007)
    • Article  

      Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation 

      Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)
      The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...
    • Article  

      Image-based biomechanics of collagen-based tissue equivalents 

      Barocas, V. Η; Sander, E.; Stylianopoulos, T.; Tranquillo, R. (2009)
    • Conference Object  

      Image-based multiscale modeling of collagen tissue-equivalents: Comparison of predicted fiber mechanics with polarimetric imaging 

      Barocas, V. Η; Sander, E. A.; Stylianopoulos, T.; Tranquillo, R. T. (Affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Sander, E. A.Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2009)
    • Article  

      Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels 

      Barocas, V. Η; Sander, E. A.; Stylianopoulos, T.; Tranquillo, R. T. (2009)
      The mechanical environment plays an important role in cell signaling and tissue homeostasis. Unraveling connections between externally applied loads and the cellular response is often confounded by extracellular matrix ...
    • Conference Object  

      In vitro prefailure mechanics of placental membranes 

      Barocas, V. Η; Oyen, M. L. L.; Stylianopoulos, T.; Calvin, S. E.; Landers, D. V. (Affiliation: Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, MN, United StatesAffiliation: Department of Chemical Engineering, University of Minnesota, Minneapolis, MN, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United StatesCorrespondence Address: Oyen, M.L.L.Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, MN, United States, 2005)
    • Article  

      Microstructure-based, multiscale modeling for the mechanical behavior of hydrated fiber networks 

      Barocas, V. Η; Chandran, P. L.; Stylianopoulos, T. (2008)
      A multiscale formulation is derived for the mechanics of a dilute fiber network microstructure, as occurs in in vitro reconstituted collagen gels, to accommodate the deterministic solution of a uniform-stress condition in ...
    • Conference Object  

      Modeling of collagen gels: A microstructural approach 

      Barocas, V. Η; Stylianopoulos, T. (Affiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
    • Article  

      Multiscale computation for bioartificial soft tissues with complex geometries 

      Barocas, V. Η; Luo, X.-J.; Stylianopoulos, T.; Shephard, M. S. (2009)
      The mechanical function of soft collagenous tissues is inherently multiscale, with the tissue dimension being in the centimeter length scale and the underlying collagen network being in the micrometer length scale. This ...
    • Conference Object  

      Multiscale, adaptive finite element computations for soft tissue biomechanics 

      Barocas, V. Η; Stylianopoulos, T.; Luo, X.; Shephard, M. S. (Affiliation: Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Scientific Computation Research Center (SCOREC), Rensselaer Polytechnic Institute, Troy, NY 12180, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2007)
    • Article  

      Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      Passive elastic behavior of arterial wall remains difficult to model. Although phenomenological and structural models exist, the question of how the three-dimensional network structure of the collagen in the artery determines ...
    • Conference Object  

      Permeability calculations in three-dimensional fiber networks 

      Barocas, V. Η; Stylianopoulos, T.; Yeckel, A.; Derby, J. J.; Luo, X. J.; Shephard, M. S.; Sander, E. A. (Affiliation: Department of Chemical Engineering, University of Minnesota, United StatesAffiliation: Scientific Computation Research Center (SCOREC), RPIAffiliation: Department of Biomedical Engineering, University of Minnesota, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering, University of MinnesotaUnited States, 2009)
    • Conference Object  

      Permeability calculations in three-dimensional fiber networks with varying degrees of orientation 

      Barocas, V. Η; Stylianopoulos, T.; Yeckel, A.; Derby, J. J.; Luo, X.-J.; Shephard, M. (Affiliation: Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02129, United StatesAffiliation: Chemical Engineering and Materials Science, University of Minnesota, 151 Amundson Hall, Minneapolis, MN 55455-0132, United StatesAffiliation: Scientific Computation Research Center, Rensselaer Polytechnic Institute, Troy, NY 12180, United StatesCorrespondence Address: Stylianopoulos, T.Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02129, United States, 2008)
    • Article  

      Permeability calculations in three-dimensional isotropic and oriented fiber networks 

      Barocas, V. Η; Stylianopoulos, T.; Yeckel, A.; Derby, J. J.; Luo, X.-J.; Shephard, M. S.; Sander, E. A. (2008)
      Hydraulic permeabilities of fiber networks are of interest for many applications and have been studied extensively. There is little work, however, on permeability calculations in three-dimensional random networks. Computational ...
    • Conference Object  

      Single-scale and multiscale models of tissue-equivalent mechanics 

      Barocas, V. Η; Chandran, P. L.; Stylianopoulos, T.; Evans, M. C.; Ohsumi, T. K.; Flaherty, J. E. (Affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Computer Science, Colgate University, Hamilton, NY 13346, United StatesAffiliation: Department of Computer Science, Rensselaer Polytechnic Institute, Troy, NY 12180, United StatesCorrespondence Address: Chandran, P.L.Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
    • Conference Object  

      A structural, kinetic model of soft tissue thermomechanics 

      Barocas, V. Η; Stylianopoulos, T.; Aksan, A. (Affiliation: Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2007)
    • Article  

      A structural, kinetic model of soft tissue thermomechanics 

      Barocas, V. Η; Stylianopoulos, T.; Aksan, A. (2008)
      A structure-based kinetic model was developed to predict the thermomechanical response of collagenous soft tissues. The collagen fibril was represented as an ensemble of molecular arrays with cross-links connecting the ...
    • Conference Object  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Stylianopoulos, T.; Calvin, S. E.; Cook, R. F. (Affiliation: Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Minnesota Perinatal Physicians/Allina Health System, Minneapolis, MN 55407, United StatesCorrespondence Address: Oyen, M.L.Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
      Chorioamnion, the membrane surrounding a fetus during gestation (the "amniotic sac"), is a structural soft tissue for which the mechanical behavior is poorly understood-despite its critical role in maintaining a successful ...
    • Article  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Cook, R. F.; Stylianopoulos, T.; Calvin, S. E.; Landers, D. V. (2005)
      Chorioamnion, the membrane surrounding a fetus during gestation, is a structural soft tissue critical for maintaining a successful pregnancy and delivery. However, the mechanical behavior of this tissue membrane is poorly ...
    • Article  

      Volume-averaging theory for the study of the mechanics of collagen networks 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      A multiscale methodology has been developed for modeling mechanical behavior of collagen fiber networks. The methodology addresses scale separation between the macroscopic, tissue-level scale and the microscopic, fiber-level ...