Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Bawendi, M. G."
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Article
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
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Article
Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions
Stylianopoulos, T.; Poh, M. Z.; Insin, N.; Bawendi, M. G.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2010)Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and separation processes. Experimental findings have shown that ...
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Multistage nanoparticle delivery system for deep penetration into tumor tissue
Wong, C.; Stylianopoulos, T.; Cui, J.; Martin, J.; Chauhan, V. P.; Jiang, W.; Popovic, Z.; Jain, R. K.; Bawendi, M. G.; Fukumura, D. (2011)Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
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Article
Multistage nanoparticles for improved delivery into tumor tissue
Stylianopoulos, T.; Wong, C.; Bawendi, M. G.; Jain, R. K.; Fukumura, D. (2012)The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
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Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
Chauhan, V. P.; Stylianopoulos, T.; Martin, J. D.; PopoviÄ, Z.; Chen, O.; Kamoun, W. S.; Bawendi, M. G.; Fukumura, D.; Jain, R. K. (2012)The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...