Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Munn, L. L."

Now showing items 1-8 of 8

    • Article  

      Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)
      The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
    • Article  

      Diffusion anisotropy in collagen gels and tumors: The effect of fiber network orientation 

      Stylianopoulos, T.; Diop-Frimpong, B.; Munn, L. L.; Jain, R. K. (2010)
      The interstitial matrix is comprised of cross-linked collagen fibers, generally arranged in nonisotropic orientations. Spatial alignment of matrix components within the tissue can affect diffusion patterns of drugs. In ...
    • Article  

      Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions 

      Stylianopoulos, T.; Poh, M. Z.; Insin, N.; Bawendi, M. G.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2010)
      Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and separation processes. Experimental findings have shown that ...
    • Conference Object  

      In vivo imaging of microvasculature using optical coherence tomography 

      Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (Correspondence Address: Vakoc, B. J., 2010)
      In vivo imaging technologies drive the development of improved cancer therapies by revealing critical aspects of the complex pathophysiology of solid tumors in small animal models[1]. The abnormal vascular function, which ...
    • Article  

      Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy 

      Stylianopoulos, T.; Munn, L. L.; Jain, R. K. (2018)
      [Figure presented] A solid tumor is like an aberrant organ – comprised of cancer cells and a variety of host cells embedded in an extracellular matrix – nourished by blood vessels and drained by lymphatic vessels. In its ...
    • Conference Object  

      Residual stresses in solid tumors: Implications to tumor growth and drug delivery 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Munn, L. L.; Jain, R. K. (Affiliation: Edwin L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United StatesAffiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusCorrespondence Address: Edwin L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United States, 2012)
    • Article  

      Scaling rules for diffusive drug delivery in tumor and normal tissues 

      Baish, J. W.; Stylianopoulos, T.; Lanning, R. M.; Kamoun, W. S.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2011)
      Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
    • Article  

      Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging 

      Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (2009)
      Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...