Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Voutouri, C."
Now showing items 1-13 of 13
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Article
Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness
Voutouri, C.; Stylianopoulos, T. (2018)Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major ...
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Article
Amphiphilic Polymer Conetworks Based on End-Linked "core-First" Star Block Copolymers: Structure Formation with Long-Range Order
Kepola, E. J.; Loizou, E.; Patrickios, C. S.; Leontidis, E.; Voutouri, C.; Stylianopoulos, T.; Schweins, R.; Gradzielski, M.; Krumm, C.; Tiller, J. C.; Kushnir, M.; Wesdemiotis, C. (2015)Amphiphilic polymer conetworks are cross-linked polymers that swell both in water and in organic solvents and can phase separate on the nanoscale in the bulk or in selective solvents. To date, however, this phase separation ...
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Conference Object
Double-hydrophilic semi-interpenetrating hydrogels with tunable and predictable mechanical performance
Papaparaskeva, G,; Voutouri, C.; Gkretsi, V.; Achilleos, M.; Safarik, I.; Pospiskova, K.; Stylianopoulos, T.; Krasia‐Christoforou, Theodora (2018)
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Article
Double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization
Kitiri, E. N.; Patrickios, C. S.; Voutouri, C.; Stylianopoulos, T.; Hoffmann, I.; Schweins, R.; Gradzielski, M. (2017)This manuscript presents the preparation and study of a new double-network hydrogel system, comprising an amphiphilic, pH-responsive first polymer conetwork synthesized via reversible addition-fragmentation chain transfer ...
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Article
Evolution of osmotic pressure in solid tumors
Voutouri, C.; Stylianopoulos, T. (2014)The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...
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Article
Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy
Voutouri, C.; Polydorou, C.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2016)Despite the important role that mechanical forces play in tumor growth and therapy, the contribution of swelling to tumor mechanopathology remains unexplored. Tumors rich in hyaluronan exhibit a highly negative fixed charge ...
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Article
Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
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Article
Pirfenidone normalizes the tumor microenvironment to improve chemotherapy
Polydorou, C.; Mpekris, F.; Papageorgis, P.; Voutouri, C.; Stylianopoulos, T. (2017)Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion ...
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Article
Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Article
Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...
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Article
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
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Article
Stress alleviation strategy in cancer treatment: Insights from a mathematical model
Mpekris, F.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T. (2018)Tumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels-while nourishing the tumor-are usually ...
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Article
Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Papageorgis, P.; Polydorou, C.; Mpekris, F.; Voutouri, C.; Agathokleous, E.; Kapnissi-Christodoulou, C. P.; Stylianopoulos, T. (2017)Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and ...