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dc.contributor.authorIzamis, Maria-Louisaen
dc.contributor.authorEfstathiades, Andreasen
dc.contributor.authorKeravnou, Christinaen
dc.contributor.authorLeen, Edward L.en
dc.contributor.authorAVERKIOU, MICHALAKIS A.en
dc.creatorIzamis, Maria-Louisaen
dc.creatorEfstathiades, Andreasen
dc.creatorKeravnou, Christinaen
dc.creatorLeen, Edward L.en
dc.creatorAVERKIOU, MICHALAKIS A.en
dc.date.accessioned2019-05-06T12:23:45Z
dc.date.available2019-05-06T12:23:45Z
dc.date.issued2014
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48435
dc.description.abstractThe aim of this study was to enable investigations into novel imaging and surgical techniques by developing a readily accessible, versatile liver machine perfusion system. Slaughterhouse pig livers were used, and dynamic contrast-enhanced ultrasound was introduced to optimize the procurement process and provide real-time perfusion monitoring. The system comprised a single pump, oxygenator, bubble trap and two flowmeters for pressure-controlled perfusion of the vessels using an off-the-shelf perfusate at room temperature. Successful livers exhibited homogeneous perfusion in both the portal vein and hepatic artery with dynamic contrast-enhanced ultrasound, which correlated with stable oxygen uptake, bile production and hepatic resistance and normal histology at the end of 3 h of perfusion. Dynamic contrast-enhanced ultrasound revealed perfusion abnormalities invisible to the naked eye, thereby providing context to the otherwise systemic biochemical/hemodynamic measurements and focal biopsy findings. The model developed here is a simple, cost-effective approach for stable ex vivo whole-organ machine perfusion.en
dc.sourceUltrasound in medicine & biologyen
dc.titleOriginal Contribution: Dynamic Contrast-Enhanced Ultrasound of Slaughterhouse Porcine Livers in Machine Perfusionen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ultrasmedbio.2014.03.031
dc.description.volume40
dc.description.startingpage2217
dc.description.endingpage2230
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidAverkiou, Michalakis A. [0000-0002-2485-3433]
dc.description.totalnumpages2217-2230


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