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dc.contributor.authorPapageorgis, P.en
dc.contributor.authorStylianopoulos, T.en
dc.creatorPapageorgis, P.en
dc.creatorStylianopoulos, T.en
dc.date.accessioned2019-05-06T12:24:17Z
dc.date.available2019-05-06T12:24:17Z
dc.date.issued2015
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48694
dc.description.abstractDeregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of various tissues in an autocrine and paracrine manner. Aberrant activity of TGFβ signaling is well known to play dual roles in cancer, depending on tumor stage and cellular context. The crucial roles of TGFβ in modulating the tumor microenvironment, its contribution to the accumulation of mechanical forces within the solid constituents of a tumor and its effects on the effective delivery of drugs are also becoming increasingly clear. In this review, we discuss the latest advances in the efforts to unravel the effects of TGFβ signaling in various components of the tumor microenvironment and how these influence the generation of forces and the efficacy of drugs. We also report the implications of tumor mechanics in cancer therapy and the potential usage of anti-TGFβ agents to enhance drug delivery and augment existing therapeutic approaches. These findings provide new insights towards the significance of targeting TGFβ pathway to enhance personalized tumor treatment.en
dc.language.isoengen
dc.sourceInternational journal of oncologyen
dc.subjectantineoplastic agenten
dc.subjectAntineoplastic Agentsen
dc.subjecthumanen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectpriority journalen
dc.subjectmetastasisen
dc.subjecttumor microenvironmenten
dc.subjectcell proliferationen
dc.subjectproceduresen
dc.subjectpathologyen
dc.subjectsignal transductionen
dc.subjecttransforming growth factor betaen
dc.subjecttumor growthen
dc.subjectArticleen
dc.subjectmolecularly targeted therapyen
dc.subjectmetabolismen
dc.subjectprotein targetingen
dc.subjectgeneticsen
dc.subjectphysiologyen
dc.subjectdrug effectsen
dc.subjectdrug delivery systemen
dc.subjectepithelial mesenchymal transitionen
dc.subjectExtracellular matrixen
dc.subjectCancer therapyen
dc.subjectantagonists and inhibitorsen
dc.subjectDesmoplasiaen
dc.subjectfibroblasten
dc.subjectimmunocompetent cellen
dc.subjectCancer-associated fibroblastsen
dc.subjectdrug repositioningen
dc.subjectImmune cellsen
dc.subjectMolecular Targeted Therapyen
dc.subjectprotein synthesisen
dc.titleRole of TGFβ in regulation of the tumor microenvironment and drug delivery (review)en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3892/ijo.2015.2816
dc.description.volume46
dc.description.startingpage933
dc.description.endingpage943
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages933-943
dc.gnosis.orcid0000-0002-3093-1696


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