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dc.contributor.authorRadhakrishnan, H.en
dc.contributor.authorKassinos, Stavros C.en
dc.creatorRadhakrishnan, H.en
dc.creatorKassinos, Stavros C.en
dc.date.accessioned2019-05-06T12:24:24Z
dc.date.available2019-05-06T12:24:24Z
dc.date.issued2009
dc.identifier.isbn978-3-642-03881-5
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48743
dc.description.abstractUnderstanding transport and deposition of inhaled particles in the human airways plays a crucial role in the targeted therapy of pulmonary diseases, and the administration of inhaled medicines. Numerous researchers have studied the inhalation of particles using experiments or computer models. Even though experiments have shown that the airflow in the trachea and the upper branches of the lung is turbulent, the flow is taken to be laminar in most computer models. Only few recently published papers have looked at the turbulent transport of air in the human airways. Even fewer results have been published on the effect of the upper airway structures on the turbulent airflow in the lungs or on the effect of the turbulence on particle deposition. The previously published turbulent models have also mainly used RANS methods to predict the flow. To study the unsteady flow and particle deposition in a human lung, an LES model with a dynamic Smagorinsky sub-grid scale model was used. The model equations were solved to study steady inspirational flow at different flow rates for different particle sizes. Results indicate that the upper airway geometry produces turbulence in the flow and the deposition of particles is mainly affected by the particle size and Stokes number.en
dc.language.isoengen
dc.publisherAffiliation: UCY-CompSci Computational Sciences Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprusen
dc.publisherCorrespondence Address: Radhakrishnan, H.en
dc.publisherUCY-CompSci Computational Sciences Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprusen
dc.sourceIFMBE Proceedingsen
dc.subjectImaging systemsen
dc.subjectTurbulenceen
dc.subjectNumerical modelingen
dc.subjectExperimentsen
dc.subjectModel equationsen
dc.subjectDepositionen
dc.subjectLarge eddy simulationen
dc.subjectParticle sizeen
dc.subjectStokes numberen
dc.subjectParticle depositionen
dc.subjectUpper airwayen
dc.subjectParticle depositionsen
dc.subjectHuman airwaysen
dc.subjectMedical imagingen
dc.subjectBiological organsen
dc.subjectMedicineen
dc.subjectImage processingen
dc.subjectBiophysicsen
dc.subjectComputer modelsen
dc.subjectDisease controlen
dc.subjectHuman airwayen
dc.subjectHuman lungen
dc.subjectInhaled particlesen
dc.subjectLarge eddy simulationsen
dc.subjectRespiratory mechanicsen
dc.subjectSub-grid scale modelsen
dc.subjectTurbulent modelsen
dc.subjectTurbulent transportsen
dc.titleNumerical modeling of turbulent airflow and particle deposition in a bifurcating airway modelen
dc.typeinfo:eu-repo/semantics/conferenceObject
dc.identifier.doi10.1007/978-3-642-03882-2-554
dc.description.volume25
dc.description.startingpage2089
dc.description.endingpage2092
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeConference Objecten
dc.contributor.orcidKassinos, Stavros C. [0000-0002-3501-3851]
dc.description.totalnumpages2089-2092


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