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dc.contributor.authorSboros, Vassilisen
dc.contributor.authorAVERKIOU, MICHALAKIS A.en
dc.contributor.authorLampaskis, M.en
dc.contributor.authorThomas, D. H.en
dc.contributor.authorSilva, N.en
dc.contributor.authorStrouthos, Costasen
dc.contributor.authorDocherty, J.en
dc.contributor.authorMcNeilly, A. S.en
dc.creatorSboros, Vassilisen
dc.creatorAVERKIOU, MICHALAKIS A.en
dc.creatorLampaskis, M.en
dc.creatorThomas, D. H.en
dc.creatorSilva, N.en
dc.creatorStrouthos, Costasen
dc.creatorDocherty, J.en
dc.creatorMcNeilly, A. S.en
dc.date.accessioned2019-05-06T12:24:34Z
dc.date.available2019-05-06T12:24:34Z
dc.date.issued2011
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48811
dc.description.abstractUltrasound contrast agents have been the subject of microvascular imaging research. The sheep corpus luteum (CL) is a microvascular tissue that provides a natural angiogenic and antiangiogenic process, which changes during the luteal phase of the estrous cycle of the ewe. It can also be controlled and monitored endocrinologically, providing a very attractive in vivo model for the study and development of microvascular measurement. The perfusion of the fully developed CL between days 8 and 12 of the estrous cycle was studied in six ewes. A Philips iU22 ultrasound scanner (Bothell, WA, USA) with the linear array probe L9-3 was used to capture contrast-enhanced images after an intravenous bolus injection of 2.4 mL SonoVue (Bracco S.P.A., Milan, Italy). Time-intensity curves of a region of interest inside the CL were formed from linearized image data. A lagged-normal model to simulate the compartmental kinetics of the microvascular flow was used to fit the data, and the wash-in time was measured. Good contrast enhancement was observed in the CLs of all animals and the wash-in time averaged at 5.5 s with 9% uncertainty. The regression coefficient was highly significant for all fits. These data correlated with stained endothelial area in the histology performed postmortem. Two ewes were injected with prostaglandin F2alpha to induce CL regression, which resulted in an increase of wash-in time after a few hours. The CL of the ewe is thus proposed as an ideal model for the study and development of microvascular measurements using contrast ultrasound. Our initial results demonstrate a highly reproducible model for the study of the microvascular hemodynamics in a range of tissues and organs. (E-mail: Vassilis.Sboros@ed.ac.uk) "en
dc.sourceUltrasound in Medicine & Biologyen
dc.subjectUltrasounden
dc.subjectMicrobubbleen
dc.subjectContrast imagingen
dc.subjectheep ovaryen
dc.subjectSonoVueen
dc.subjectTracer kineticsen
dc.titleImaging of the Ovine Corpus Luteum Microcirculation with Contrast Ultrasounden
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doihttps://doi.org/10.1016/j.ultrasmedbio.2010.10.013
dc.description.volume37
dc.description.startingpage59
dc.description.endingpage68
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidAverkiou, Michalakis A. [0000-0002-2485-3433]
dc.description.totalnumpages59-68


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