dc.contributor.author | Abecasis, A. B. | en |
dc.contributor.author | Wensing, A. M. J. | en |
dc.contributor.author | Paraskevis, Dimitrios N. | en |
dc.contributor.author | Vercauteren, J. | en |
dc.contributor.author | Theys, K. | en |
dc.contributor.author | Van de Vijver, D. A. M. C. | en |
dc.contributor.author | Albert, Jan | en |
dc.contributor.author | Åsjö, Birgitta | en |
dc.contributor.author | Balotta, Claudia | en |
dc.contributor.author | Beshkov, Danail | en |
dc.contributor.author | Camacho, Ricardo J. | en |
dc.contributor.author | Clotet, B. | en |
dc.contributor.author | De Gascun, C. | en |
dc.contributor.author | Griskevicius, A. | en |
dc.contributor.author | Grossman, Z. | en |
dc.contributor.author | Hamouda, O. | en |
dc.contributor.author | Horban, A. | en |
dc.contributor.author | Kolupajeva, T. | en |
dc.contributor.author | Korn, K. | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.contributor.author | Kücherer, C. | en |
dc.contributor.author | Liitsola, K. | en |
dc.contributor.author | Linka, M. | en |
dc.contributor.author | Nielsen, C. | en |
dc.contributor.author | Otelea, D. | en |
dc.contributor.author | Paredes, R. | en |
dc.contributor.author | Poljak, M. | en |
dc.contributor.author | Puchhammer-Stöckl, E. | en |
dc.contributor.author | Schmit, J. -C | en |
dc.contributor.author | Sönnerborg, A. | en |
dc.contributor.author | Stanekova, D. | en |
dc.contributor.author | Stanojevic, M. | en |
dc.contributor.author | Struck, D. | en |
dc.contributor.author | Boucher, C. A. B. | en |
dc.contributor.author | Vandamme, A. -M | en |
dc.creator | Abecasis, A. B. | en |
dc.creator | Wensing, A. M. J. | en |
dc.creator | Paraskevis, Dimitrios N. | en |
dc.creator | Vercauteren, J. | en |
dc.creator | Theys, K. | en |
dc.creator | Van de Vijver, D. A. M. C. | en |
dc.creator | Albert, Jan | en |
dc.creator | Åsjö, Birgitta | en |
dc.creator | Balotta, Claudia | en |
dc.creator | Beshkov, Danail | en |
dc.creator | Camacho, Ricardo J. | en |
dc.creator | Clotet, B. | en |
dc.creator | De Gascun, C. | en |
dc.creator | Griskevicius, A. | en |
dc.creator | Grossman, Z. | en |
dc.creator | Hamouda, O. | en |
dc.creator | Horban, A. | en |
dc.creator | Kolupajeva, T. | en |
dc.creator | Korn, K. | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.creator | Kücherer, C. | en |
dc.creator | Liitsola, K. | en |
dc.creator | Linka, M. | en |
dc.creator | Nielsen, C. | en |
dc.creator | Otelea, D. | en |
dc.creator | Paredes, R. | en |
dc.creator | Poljak, M. | en |
dc.creator | Puchhammer-Stöckl, E. | en |
dc.creator | Schmit, J. -C | en |
dc.creator | Sönnerborg, A. | en |
dc.creator | Stanekova, D. | en |
dc.creator | Stanojevic, M. | en |
dc.creator | Struck, D. | en |
dc.creator | Boucher, C. A. B. | en |
dc.creator | Vandamme, A. -M | en |
dc.date.accessioned | 2019-11-04T12:50:10Z | |
dc.date.available | 2019-11-04T12:50:10Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1742-4690 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52912 | |
dc.description.abstract | Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.Results: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM > IDUs > heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots.Conclusions: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients. © 2013 Abecasis et al. | en |
dc.description.abstract | licensee BioMed Central Ltd. | en |
dc.source | Retrovirology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872127915&doi=10.1186%2f1742-4690-10-7&partnerID=40&md5=8d79fc7ef6c8d71563ce1279b29b3383 | |
dc.subject | Europe | en |
dc.subject | demography | en |
dc.subject | article | en |
dc.subject | Social Behavior | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | adult | en |
dc.subject | female | en |
dc.subject | major clinical study | en |
dc.subject | Socioeconomic Factors | en |
dc.subject | computer program | en |
dc.subject | male | en |
dc.subject | amino acid sequence | en |
dc.subject | Risk Factors | en |
dc.subject | sex difference | en |
dc.subject | epidemic | en |
dc.subject | HIV Infections | en |
dc.subject | intravenous drug abuse | en |
dc.subject | virus transmission | en |
dc.subject | Risk-Taking | en |
dc.subject | heterosexuality | en |
dc.subject | Human immunodeficiency virus 1 | en |
dc.subject | HIV-1 | en |
dc.subject | Human immunodeficiency virus 1 infection | en |
dc.subject | homosexuality | en |
dc.subject | molecular epidemiology | en |
dc.subject | Epidemics | en |
dc.subject | phylogenetic tree | en |
dc.subject | immigrant | en |
dc.subject | Portugal | en |
dc.subject | Poland | en |
dc.subject | Bayes Theorem | en |
dc.subject | cladistics | en |
dc.subject | genetic recombination | en |
dc.subject | Israel | en |
dc.subject | Slovenia | en |
dc.subject | virus typing | en |
dc.title | HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1186/1742-4690-10-7 | |
dc.description.volume | 10 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Tradenames: REGA Subtyping | en |
dc.description.notes | Cited By :55</p> | en |
dc.source.abbreviation | Retrovirology | en |
dc.contributor.orcid | Paraskevis, Dimitrios [0000-0001-6167-7152] | |
dc.gnosis.orcid | 0000-0001-6167-7152 | |