dc.contributor.author | Apidianakis, Yiorgos | en |
dc.contributor.author | Nagel, A. C. | en |
dc.contributor.author | Chalkiadaki, Angeliki | en |
dc.contributor.author | Preiss, A. | en |
dc.contributor.author | Delidakis, Christos | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.creator | Nagel, A. C. | en |
dc.creator | Chalkiadaki, Angeliki | en |
dc.creator | Preiss, A. | en |
dc.creator | Delidakis, Christos | en |
dc.date.accessioned | 2019-11-04T12:50:13Z | |
dc.date.available | 2019-11-04T12:50:13Z | |
dc.date.issued | 1999 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52936 | |
dc.description.abstract | Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and negative signal transducers be orchestrated around each instance of signalling. In Drosophila the basic-helix-loop-helix (bHLH) repressor encoding genes of the E(spl) locus are induced by Notch signalling and mediate some of its effects, such as suppression of neural fate. Here we report on a novel family of Notch responsive genes, whose products appear to act as antagonists of the Notch signal in the process of adult sensory organ precursor singularization. They, too, reside in the E(spl) locus and comprise transcription units E(spl) m4 and E(spl) mα. Overexpression of these genes causes downregulation of E(spl) bHLH expression accompanied by cell autonomous overcommitment of sensory organ precursors and tufting of bristles. Interestingly, negative regulation of the Notch pathway by overexpression of E(spl) m4 and mα is specific to the process of sensory organ precursor singularization and does not impinge on other instances of Notch signalling. Copyright (C) 1999 Elsevier Science Ireland Ltd. | en |
dc.source | Mechanisms of development | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032588466&doi=10.1016%2fS0925-4773%2899%2900099-4&partnerID=40&md5=19cef426bcaa38fb46f03b58a6c3819a | |
dc.subject | E(spl)mα | el |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | amino acid sequence | en |
dc.subject | down regulation | en |
dc.subject | gene expression regulation | en |
dc.subject | nonhuman | en |
dc.subject | signal transduction | en |
dc.subject | metabolism | en |
dc.subject | molecular genetics | en |
dc.subject | phenotype | en |
dc.subject | Animals | en |
dc.subject | animal | en |
dc.subject | animal experiment | en |
dc.subject | genetics | en |
dc.subject | genetic transcription | en |
dc.subject | physiology | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | gene overexpression | en |
dc.subject | transcription factor | en |
dc.subject | Transcription Factors | en |
dc.subject | DNA-Binding Proteins | en |
dc.subject | Membrane Proteins | en |
dc.subject | membrane protein | en |
dc.subject | Lateral inhibition | en |
dc.subject | Neurons | en |
dc.subject | Down-Regulation | en |
dc.subject | Transcription, Genetic | en |
dc.subject | sequence homology | en |
dc.subject | Sequence Homology, Amino Acid | en |
dc.subject | Animals, Genetically Modified | en |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | en |
dc.subject | Drosophila | en |
dc.subject | Drosophila Proteins | en |
dc.subject | Gene Expression Regulation, Developmental | en |
dc.subject | Insect Proteins | en |
dc.subject | repressor protein | en |
dc.subject | Repressor Proteins | en |
dc.subject | basic helix loop helix transcription factor | en |
dc.subject | central nervous system | en |
dc.subject | DNA binding protein | en |
dc.subject | Drosophila protein | en |
dc.subject | E(spl) locus | en |
dc.subject | E(spl) region transcript mdelta protein, Drosophila | en |
dc.subject | E(spl)m4 | en |
dc.subject | enhancer of split protein, Drosophila | en |
dc.subject | helix loop helix protein | en |
dc.subject | Helix-Loop-Helix Motifs | en |
dc.subject | insect protein | en |
dc.subject | Intercellular signalling | en |
dc.subject | m4 protein, Drosophila | en |
dc.subject | nerve cell | en |
dc.subject | notch protein, Drosophila | en |
dc.subject | Notch receptor | en |
dc.subject | Notch signalling | en |
dc.subject | precursor | en |
dc.subject | Receptors, Notch | en |
dc.subject | sense organ | en |
dc.subject | Sense Organs | en |
dc.subject | Sensory organ precursor specification | en |
dc.subject | transgenic animal | en |
dc.title | Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/S0925-4773(99)00099-4 | |
dc.description.volume | 86 | |
dc.description.startingpage | 39 | |
dc.description.endingpage | 50 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :19</p> | en |
dc.source.abbreviation | Mech.Dev. | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 | |