Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells
dc.contributor.author | Bangi, E. | en |
dc.contributor.author | Pitsouli, Chrysoula | en |
dc.contributor.author | Rahme, L. G. | en |
dc.contributor.author | Cagan, R. | en |
dc.contributor.author | Apidianakis, Yiorgos | en |
dc.creator | Bangi, E. | en |
dc.creator | Pitsouli, Chrysoula | en |
dc.creator | Rahme, L. G. | en |
dc.creator | Cagan, R. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.date.accessioned | 2019-11-04T12:50:15Z | |
dc.date.available | 2019-11-04T12:50:15Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1469-221X | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52946 | |
dc.description.abstract | Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human intestinal colonizer Pseudomonas aeruginosa synergizes with the Ras1 V12 oncogene to induce basal invasion and dissemination of hindgut cells to distant sites. Cross-talk between infection and dissemination requires sustained activation by the bacteria of the Imd-dTab2-dTak1 innate immune pathway, which converges with Ras1 V12 signalling on JNK pathway activation, culminating in extracellular matrix degradation. Hindgut, but not midgut, cells are amenable to this cooperative dissemination, which is progressive and genetically and pharmacologically inhibitable. Thus, Drosophila hindgut provides a valuable system for the study of intestinal malignancies. ©2012 European Molecular Biology Organization. | en |
dc.source | EMBO reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861843116&doi=10.1038%2fembor.2012.44&partnerID=40&md5=462ac5dc389c36c21366cdf6daeada31 | |
dc.subject | article | en |
dc.subject | cancer | en |
dc.subject | cancer growth | en |
dc.subject | priority journal | en |
dc.subject | colorectal cancer | en |
dc.subject | Colorectal Neoplasms | en |
dc.subject | nonhuman | en |
dc.subject | immune response | en |
dc.subject | innate immunity | en |
dc.subject | Animals | en |
dc.subject | animal tissue | en |
dc.subject | Host-Pathogen Interactions | en |
dc.subject | Signal Transduction | en |
dc.subject | Epithelial Cells | en |
dc.subject | protein degradation | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | ras Proteins | en |
dc.subject | Cell Movement | en |
dc.subject | Drosophila | en |
dc.subject | Drosophila Proteins | en |
dc.subject | Gastrointestinal Tract | en |
dc.subject | JNK Mitogen-Activated Protein Kinases | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Amino Acid Substitution | en |
dc.subject | Immunity, Innate | en |
dc.subject | intestine | en |
dc.subject | intestine epithelium cell | en |
dc.subject | Oncogene Proteins | en |
dc.title | Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/embor.2012.44 | |
dc.description.volume | 13 | |
dc.description.startingpage | 569 | |
dc.description.endingpage | 576 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :24</p> | en |
dc.source.abbreviation | EMBO Rep. | en |
dc.contributor.orcid | Pitsouli, Chrysoula [0000-0003-4074-9684] | |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0003-4074-9684 | |
dc.gnosis.orcid | 0000-0002-7465-3560 |
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