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Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats

dc.contributor.authorBurdette, J. E.en
dc.contributor.authorLiu, J.en
dc.contributor.authorLantvit, D.en
dc.contributor.authorLim, E.en
dc.contributor.authorBooth, N.en
dc.contributor.authorBhat, K. P. L.en
dc.contributor.authorHedayat, S.en
dc.contributor.authorVan Breemen, R. B.en
dc.contributor.authorConstantinou, Andreas I.en
dc.contributor.authorPezzuto, J. M.en
dc.contributor.authorFarnsworth, N. R.en
dc.contributor.authorBolton, J. L.en
dc.creatorBurdette, J. E.en
dc.creatorLiu, J.en
dc.creatorLantvit, D.en
dc.creatorLim, E.en
dc.creatorBooth, N.en
dc.creatorBhat, K. P. L.en
dc.creatorHedayat, S.en
dc.creatorVan Breemen, R. B.en
dc.creatorConstantinou, Andreas I.en
dc.creatorPezzuto, J. M.en
dc.creatorFarnsworth, N. R.en
dc.creatorBolton, J. L.en
dc.date.accessioned2019-11-04T12:50:17Z
dc.date.available2019-11-04T12:50:17Z
dc.date.issued2002
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/52959
dc.description.abstractStudies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones was administered by gavage [250, 500 and 750 mg/(kg·d)] to virgin, ovariectomized 50-d-old Sprague-Dawley rats, for 21 d in the presence and absence of 17β-estradiol [50μg/(kg·d)]. Estrogenic effects included an increase in uterine weight, vaginal cell cornification and mammary gland duct branching. Red clover produced a dose-dependent increase in uterine weight and differentiated vaginal cells at the two higher doses, but it did not stimulate cell proliferation in the mammary glands. Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model.en
dc.sourceJournal of Nutritionen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0036137967&partnerID=40&md5=f8e632e4b6cb5272c7c31ff3ed38d458
dc.subjectarticleen
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectCell Divisionen
dc.subjectcell proliferationen
dc.subjectunclassified drugen
dc.subjectnonhumanen
dc.subjectAnimalsen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectanimal tissueen
dc.subjectestrogen activityen
dc.subjectovariectomyen
dc.subjectplant extracten
dc.subjectAnimaliaen
dc.subjectEstrogensen
dc.subjectPlant Extractsen
dc.subjectcell stimulationen
dc.subjectcloveren
dc.subjectDose-Response Relationship, Drugen
dc.subjectestradiolen
dc.subjectEstrogenicen
dc.subjectFallopiaen
dc.subjectisoflavone derivativeen
dc.subjectIsoflavonesen
dc.subjectMammary glanden
dc.subjectMammary Glands, Animalen
dc.subjectOrgan Sizeen
dc.subjectraten
dc.subjectrat strainen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectred clover extracten
dc.subjectTrifoliumen
dc.subjectTrifolium pratenseen
dc.subjectUterusen
dc.subjectuterus weighten
dc.subjectVaginaen
dc.titleTrifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley ratsen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume132
dc.description.startingpage27
dc.description.endingpage30
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :62</p>en
dc.source.abbreviationJ.Nutr.en
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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