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dc.contributor.authorConstantinou, Andreas I.en
dc.contributor.authorLantvit, D.en
dc.contributor.authorHawthorne, M.en
dc.contributor.authorXu, X.en
dc.contributor.authorVan Breemen, R. B.en
dc.contributor.authorPezzuto, J. M.en
dc.creatorConstantinou, Andreas I.en
dc.creatorLantvit, D.en
dc.creatorHawthorne, M.en
dc.creatorXu, X.en
dc.creatorVan Breemen, R. B.en
dc.creatorPezzuto, J. M.en
dc.date.accessioned2019-11-04T12:50:22Z
dc.date.available2019-11-04T12:50:22Z
dc.date.issued2001
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/52996
dc.description.abstractThere are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female rats, mainly because of different rodent models that are used in chemoprevention studies. The present study was undertaken to compare the tumor-preventative effects of soy protein isolate (SPI) and two of its isoflavones in a "standard" model that had been used for the identification of many chemopreventive agents. Six groups of female Sprague-Dawley rats were provided with modified cornstarch AIN-76A diets supplemented as follows: no additional agents (control), purified genistein (200 mg/kg diet), purified daidzein (200 mg/kg diet), genistein + daidzein (100 mg/kg diet each), SPI containing normal levels of isoflavones (SPI-n), or SPI depleted of isoflavones (SPI-d). Mammary carcinomas were induced by 7,12-dimethyl-benz[a]anthracene (DMBA) introduced 1 wk after the animals began consuming the experimental diets. At the end of the study (120 days after DMBA treatment), no significant differences were found among the six groups with respect to tumor incidence or survival, nor was there a significant reduction in tumor multiplicity in the genistein or genistein + daidzein group. However, there was a 32% reduction in tumor multiplicity in the daidzein and SPI-n groups relative to the control group (P < 0.05). The most effective diet was SPI-d, which produced a 50% reduction in tumor multiplicity relative to the control (P < 0.01). The difference between the SPI-d group and the daidzein or SPI-n group was not significant. Median tumor latency was increased from 53 days in the control group to 68 days in the daidzein group and to 72 days in the SPI-d group, but these differences were not statistically significant. These results show that daidzein and SPI (with normal or low levels of isoflavones) are effective inhibitors of DMBA-induced mammary tumors in adult rats.en
dc.sourceNutrition and canceren
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035527479&partnerID=40&md5=02f67986027bb2ca548b68d044260c2e
dc.subjectmodelen
dc.subjectarticleen
dc.subjectantineoplastic agenten
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectsurvival rateen
dc.subjectAnticarcinogenic Agentsen
dc.subjectcancer incidenceen
dc.subjectchemically induced disorderen
dc.subjectnonhumanen
dc.subjectcomparative studyen
dc.subjectAnimalsen
dc.subjectdiet supplementationen
dc.subjectanimalen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectanimal tissueen
dc.subjectbreast carcinogenesisen
dc.subjectchemistryen
dc.subjectbreast tumoren
dc.subjectchemoprophylaxisen
dc.subjectSupport, Non-U.S. Gov'ten
dc.subjectdieten
dc.subjectSupport, U.S. Gov't, P.H.S.en
dc.subjectdaidzeinen
dc.subjectgenisteinen
dc.subjectsoybeanen
dc.subjectisoflavone derivativeen
dc.subjectIsoflavonesen
dc.subjectraten
dc.subjectrat strainen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectMammary Neoplasms, Experimentalen
dc.subject7,12 dimethylbenz[a]anthraceneen
dc.subject9,10-Dimethyl-1,2-benzanthraceneen
dc.subjectdimethylbenz[a]anthraceneen
dc.subjectexperimental neoplasmen
dc.subjectsoybean proteinen
dc.subjectSoybean Proteinsen
dc.subjectSoybeansen
dc.subjectSprague Dawley raten
dc.titleChemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley ratsen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume41
dc.description.startingpage75
dc.description.endingpage81
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Manufacturers: Indofine, United Statesen
dc.description.notesProtein Technologies, United Statesen
dc.description.notesCited By :85</p>en
dc.source.abbreviationNutr.Canceren
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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