Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis
Ημερομηνία
1995Συγγραφέας
Gerhäuser, C.Mar, W.
Lee, S. K.
Suh, N.
Luo, Y.
Kosmeder, J.
Luyengi, L.
Fong, H. H. S.
Kinghorn, A. D.
Moriarty, R. M.
Mehta, R. G.
Constantinou, Andreas I.
Moon, R. C.
Pezzuto, J. M.
ISSN
1078-8956Source
Nature medicineVolume
1Pages
260-266Google Scholar check
Keyword(s):
Metadata
Εμφάνιση πλήρους εγγραφήςΕπιτομή
For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were obtained from the African plant Mundulea sericea (Leguminosae). These isolates were highly potent when evaluated for inhibition of chemically induced preneoplastic lesions in mammary organ culture and inhibition of papillomas in the two-stage mouse skin model, and they appear to function by a unique mechanism at the level of ODC messenger RNA expression. Based on our findings, rotenoids can be regarded as promising new chemopreventive or anticancer agents. © 1995 Nature Publishing Group.