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dc.contributor.authorGerhäuser, C.en
dc.contributor.authorMar, W.en
dc.contributor.authorLee, S. K.en
dc.contributor.authorSuh, N.en
dc.contributor.authorLuo, Y.en
dc.contributor.authorLuyengi, L.en
dc.contributor.authorFong, H. H. S.en
dc.contributor.authorKinghorn, A. D.en
dc.contributor.authorMehta, R. G.en
dc.contributor.authorMar, W.en
dc.contributor.authorMehta, R. G.en
dc.contributor.authorConstantinou, Andreas I.en
dc.contributor.authorMoon, R. C.en
dc.contributor.authorPezzuto, J. M.en
dc.creatorGerhäuser, C.en
dc.creatorMar, W.en
dc.creatorLee, S. K.en
dc.creatorSuh, N.en
dc.creatorLuo, Y.en
dc.creatorLuyengi, L.en
dc.creatorFong, H. H. S.en
dc.creatorKinghorn, A. D.en
dc.creatorMehta, R. G.en
dc.creatorMar, W.en
dc.creatorMehta, R. G.en
dc.creatorConstantinou, Andreas I.en
dc.creatorMoon, R. C.en
dc.creatorPezzuto, J. M.en
dc.date.accessioned2019-11-04T12:50:39Z
dc.date.available2019-11-04T12:50:39Z
dc.date.issued1995
dc.identifier.issn1078-8956
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53105
dc.description.abstractFor the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were obtained from the African plant Mundulea sericea (Leguminosae). These isolates were highly potent when evaluated for inhibition of chemically induced preneoplastic lesions in mammary organ culture and inhibition of papillomas in the two-stage mouse skin model, and they appear to function by a unique mechanism at the level of ODC messenger RNA expression. Based on our findings, rotenoids can be regarded as promising new chemopreventive or anticancer agents. © 1995 Nature Publishing Group.en
dc.sourceNature medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84993915009&doi=10.1038%2fnm0395-260&partnerID=40&md5=6e4b1dde97d7380247e847e3a9e7db0e
dc.titleRotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylaseen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/nm0395-260
dc.description.volume1
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :8</p>en
dc.source.abbreviationNat.Med.en
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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