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Assessment of organotins against the linoleic acid, glutathione and CT-DNA

dc.contributor.authorBanti, Christina N.en
dc.contributor.authorGkaniatsou, E. I.en
dc.contributor.authorKourkoumelis, Nikolaosen
dc.contributor.authorManos, Manolis J.en
dc.contributor.authorTasiopoulos, Anastasios J.en
dc.contributor.authorBakas, Thomas V.en
dc.contributor.authorHadjikakou, Sotiris K.en
dc.creatorBanti, Christina N.en
dc.creatorGkaniatsou, E. I.en
dc.creatorKourkoumelis, Nikolaosen
dc.creatorManos, Manolis J.en
dc.creatorTasiopoulos, Anastasios J.en
dc.creatorBakas, Thomas V.en
dc.creatorHadjikakou, Sotiris K.en
dc.date.accessioned2019-11-21T06:16:48Z
dc.date.available2019-11-21T06:16:48Z
dc.date.issued2014
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55281
dc.description.abstractThe already known di-n-butyltin(IV) complex of the chiral anti-inflammatory drug naproxen (Hnapr) of formula [(n-Bu-)2Sn(nap)2] (1), was re-synthesized here with an alternative method and it was used for the assessment of organotins towards the linoleic acid which is located in the cell membrane, the intracellular glutathione and the nuclear CT-DNA. The compound was characterized by melting point (m.p.) 119Sn Mössbauer while its structure was confirmed by X-ray crystallography. The influence of 1, upon the peroxidation of linoleic acid to hydroperoxylinoleic was kinetically studied. The binding affinity of 1 towards the intracellular molecular components CT-DNA and glutathione (GSH) was studied by UV-Vis spectroscopy. © 2014 Elsevier B.V. All rights reserved.en
dc.sourceInorganica Chimica Actaen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84910107019&doi=10.1016%2fj.ica.2014.02.006&partnerID=40&md5=471238eb17df0ababb446e155d363c7a
dc.subjectGlutathioneen
dc.subjectBioinorganic chemistryen
dc.subjectCT-DNAen
dc.subjectLinoleic aciden
dc.subjectNSAIDen
dc.subjectOrganotin(IV)en
dc.titleAssessment of organotins against the linoleic acid, glutathione and CT-DNAen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ica.2014.02.006
dc.description.volume423
dc.description.issuePBen
dc.description.startingpage98
dc.description.endingpage106
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :4</p>en
dc.source.abbreviationInorg.Chim.Actaen
dc.contributor.orcidTasiopoulos, Anastasios J. [0000-0002-4804-3822]
dc.contributor.orcidHadjikakou, Sotiris K. [0000-0001-9556-6266]
dc.gnosis.orcid0000-0002-4804-3822
dc.gnosis.orcid0000-0001-9556-6266


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