dc.contributor.author | Filipiak, W. | en |
dc.contributor.author | Mochalski, Paweł | en |
dc.contributor.author | Filipiak, A. | en |
dc.contributor.author | Ager, C. | en |
dc.contributor.author | Cumeras, R. | en |
dc.contributor.author | Davis, C. E. | en |
dc.contributor.author | Agapiou, Agapios | en |
dc.contributor.author | Unterkofler, K. | en |
dc.contributor.author | Troppmair, J. | en |
dc.creator | Filipiak, W. | en |
dc.creator | Mochalski, Paweł | en |
dc.creator | Filipiak, A. | en |
dc.creator | Ager, C. | en |
dc.creator | Cumeras, R. | en |
dc.creator | Davis, C. E. | en |
dc.creator | Agapiou, Agapios | en |
dc.creator | Unterkofler, K. | en |
dc.creator | Troppmair, J. | en |
dc.date.accessioned | 2019-11-21T06:19:01Z | |
dc.date.available | 2019-11-21T06:19:01Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55477 | |
dc.description.abstract | Volatile organic compounds (VOCs) offer unique insights into ongoing biochemical processes in healthy and diseased humans. Yet, their diagnostic use is hampered by the limited understanding of their biochemical or cellular origin and their frequently unclear link to the underlying diseases. Major advancements are expected from the analyses of human primary cells, cell lines and cultures of microorganisms. In this review, a database of 125 reliably identified VOCs previously reported for human healthy and diseased cells was assembled and their potential origin is discussed. The majority of them have also been observed in studies with other human matrices (breath, urine, saliva, feces, blood, skin emanations). Moreover, continuing improvements of qualitative and quantitative analyses, based on the recommendations of the ISO-11843 guidelines, are suggested for the necessary standardization of analytical procedures and better comparability of results. The data provided contribute to arriving at a more complete human volatilome and suggest potential volatile biomarkers for future validation. © 2016 Bentham Science Publishers. | en |
dc.source | Current medicinal chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983753514&doi=10.2174%2f092986732366616031612505&partnerID=40&md5=3e92d17628a2b4d95e108125e9071681 | |
dc.subject | Standardization | en |
dc.subject | qualitative analysis | en |
dc.subject | Review | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | quantitative analysis | en |
dc.subject | blood | en |
dc.subject | Cancer | en |
dc.subject | oxidative stress | en |
dc.subject | pathology | en |
dc.subject | metabolism | en |
dc.subject | biological marker | en |
dc.subject | biochemistry | en |
dc.subject | immunoreactivity | en |
dc.subject | data base | en |
dc.subject | skin | en |
dc.subject | breathing | en |
dc.subject | cell death | en |
dc.subject | Biomarkers | en |
dc.subject | reliability | en |
dc.subject | Biomarker | en |
dc.subject | oxygen | en |
dc.subject | analytic method | en |
dc.subject | cell culture | en |
dc.subject | cell line | en |
dc.subject | sampling | en |
dc.subject | mass fragmentography | en |
dc.subject | urine | en |
dc.subject | volatile organic compound | en |
dc.subject | Volatile Organic Compounds | en |
dc.subject | Gas Chromatography-Mass Spectrometry | en |
dc.subject | limit of detection | en |
dc.subject | aldehyde dehydrogenase | en |
dc.subject | Breath analysis | en |
dc.subject | Cytochrome P-450 Enzyme System | en |
dc.subject | cytochrome P450 | en |
dc.subject | cytochrome P450 reductase | en |
dc.subject | feces | en |
dc.subject | GC-MS | en |
dc.subject | Human cell lines | en |
dc.subject | primary cell | en |
dc.subject | saliva | en |
dc.subject | Volatile organic compounds (VOCS) | en |
dc.subject | Volatilome | en |
dc.title | A compendium of volatile organic compounds (VOCs) released by human cell lines | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.2174/092986732366616031612505 | |
dc.description.volume | 23 | |
dc.description.issue | 20 | |
dc.description.startingpage | 2112 | |
dc.description.endingpage | 2131 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :1</p> | en |
dc.source.abbreviation | Curr.Med.Chem. | en |
dc.contributor.orcid | Agapiou, Agapios [0000-0001-8371-0910] | |
dc.gnosis.orcid | 0000-0001-8371-0910 | |