dc.contributor.author | Ioannidou, Heraklidia A. | en |
dc.contributor.author | Martin, A. | en |
dc.contributor.author | Gollner, A. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Ioannidou, Heraklidia A. | en |
dc.creator | Martin, A. | en |
dc.creator | Gollner, A. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:26Z | |
dc.date.available | 2019-11-21T06:19:26Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55567 | |
dc.description.abstract | Ethyl canthin-6-one-1-carboxylate (1b) and nine analogues 1c-k were prepared from readily prepared ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3- carboxylate (2b) via a three-step non-classical approach that focused on construction of the central pyrrole (ring B) using Pd-catalyzed Suzuki-Miyaura coupling followed by Cu-catalyzed C-N coupling. Furthermore, treatment of the ethyl canthinone-1-carboxylate 1b with NaOH in DCM/MeOH (9:1) gave the canthin-6-one-1-carboxylic acid (6) in high yield. All compounds are fully characterized. © 2011 American Chemical Society. | en |
dc.source | Journal of Organic Chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958824179&doi=10.1021%2fjo200824b&partnerID=40&md5=6abe4ce84c63006d39e8ea164535a914 | |
dc.subject | article | en |
dc.subject | unclassified drug | en |
dc.subject | Synthesis (chemical) | en |
dc.subject | synthesis | en |
dc.subject | copper | en |
dc.subject | chemical reaction | en |
dc.subject | reaction analysis | en |
dc.subject | Carboxylic acids | en |
dc.subject | Catalysis | en |
dc.subject | High yield | en |
dc.subject | palladium | en |
dc.subject | Molecular Structure | en |
dc.subject | Hydrolysis | en |
dc.subject | Suzuki-Miyaura coupling | en |
dc.subject | Carboxylation | en |
dc.subject | Naphthyridines | en |
dc.subject | Suzuki reaction | en |
dc.subject | amidation | en |
dc.subject | Amidation reaction | en |
dc.subject | Amination | en |
dc.subject | Bromine Compounds | en |
dc.subject | C-N coupling | en |
dc.subject | canthin 6 one 1 carboxylic acid | en |
dc.subject | carboxylic acid derivative | en |
dc.subject | ethyl 4 bromo 6 methoxy 1,5 naphthyridine 3 carboxylate | en |
dc.subject | ethyl canthinone 3 carboxylate | en |
dc.subject | Three-step synthesis | en |
dc.title | Three-step synthesis of ethyl canthinone-3-carboxylates from ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a Pd-catalyzed Suzuki-Miyaura coupling and a Cu-catalyzed amidation reaction | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1021/jo200824b | |
dc.description.volume | 76 | |
dc.description.issue | 12 | |
dc.description.startingpage | 5113 | |
dc.description.endingpage | 5122 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :20</p> | en |
dc.source.abbreviation | J.Org.Chem. | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |