dc.contributor.author | Ozturk, I. I. | en |
dc.contributor.author | Banti, Christina N. | en |
dc.contributor.author | Manos, Manolis J. | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Kourkoumelis, Nikolaos | en |
dc.contributor.author | Charalabopoulos, Konstantinos A. | en |
dc.contributor.author | Hadjikakou, Sotiris K. | en |
dc.creator | Ozturk, I. I. | en |
dc.creator | Banti, Christina N. | en |
dc.creator | Manos, Manolis J. | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Kourkoumelis, Nikolaos | en |
dc.creator | Charalabopoulos, Konstantinos A. | en |
dc.creator | Hadjikakou, Sotiris K. | en |
dc.date.accessioned | 2019-11-21T06:21:51Z | |
dc.date.available | 2019-11-21T06:21:51Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55929 | |
dc.description.abstract | Three new antimony(III) halide complexes (SbX 3, X = Cl, Br and I) with the heterocyclic thione ω-thiocaprolactam (1-azacycloheptane-2- thione, (Hthcl)) of formulae {[SbCl 2(μ 2-Cl)(Hthcl) 2] n} (1), {[(SbBr 2(μ 2-Br)(Hthcl) 2) 2]} (2) and {[(SbI 2(μ 2-I) (Hthcl) 2) 2]} (3) were synthesized from the reaction of antimony(III) halides with ω-thiocaprolactam in 1:2 stoichiometry. The complexes were characterized by elemental analysis, FT-IR spectroscopy, 1H, 13C NMR spectroscopy and Thermal Gravimetry- Differential Thermal Analysis (TG-DTA). Crystal structures of the ligand ω-thiocaprolactam and its complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1-3 and ω-thiocaprolactam were evaluated for their in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) tumor cell lines. Antimony complexes 1-3 exhibit strong antiproliferative activity against both cell lines tested. The higher such activity was found for 3 with IC 50 values of 0.12 ± 0.04 μM (LMS) and 0.76 ± 0.16 μM (MCF-7) which are 60 and 10 times respectively, stronger than that of cisplatin. The influence of these complexes 1-3 and ω-thiocaprolactam upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The results were shown negligible inhibitory activity of 1-3 against LOX. © 2012 Elsevier Inc. All rights reserved. | en |
dc.source | Journal of inorganic biochemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857388949&doi=10.1016%2fj.jinorgbio.2012.01.014&partnerID=40&md5=7ea025cf12572c68c6d71f16d4f92e07 | |
dc.subject | ω- Thiocaprolactam | el |
dc.subject | article | en |
dc.subject | antineoplastic agent | en |
dc.subject | Antineoplastic Agents | en |
dc.subject | cisplatin | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | unclassified drug | en |
dc.subject | leiomyosarcoma | en |
dc.subject | human cell | en |
dc.subject | breast adenocarcinoma | en |
dc.subject | in vitro study | en |
dc.subject | drug synthesis | en |
dc.subject | crystal structure | en |
dc.subject | X ray diffraction | en |
dc.subject | Magnetic Resonance Spectroscopy | en |
dc.subject | antimony derivative | en |
dc.subject | infrared spectroscopy | en |
dc.subject | thermogravimetry | en |
dc.subject | Antimony | en |
dc.subject | tumor cell line | en |
dc.subject | Cell Survival | en |
dc.subject | Coordination Complexes | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | cytotoxicity | en |
dc.subject | IC 50 | en |
dc.subject | Inhibitory Concentration 50 | en |
dc.subject | Models, Molecular | en |
dc.subject | Crystallography, X-Ray | en |
dc.subject | antiproliferative activity | en |
dc.subject | Crystal structures | en |
dc.subject | Bioinorganic chemistry | en |
dc.subject | halide | en |
dc.subject | carbon nuclear magnetic resonance | en |
dc.subject | Cytotoxic activity | en |
dc.subject | linoleic acid | en |
dc.subject | lipoxygenase | en |
dc.subject | Spectroscopy, Fourier Transform Infrared | en |
dc.subject | Thiones | en |
dc.subject | Antimony(III) halide complexes | en |
dc.subject | Caprolactam | en |
dc.subject | caprolactam derivative | en |
dc.subject | omega thiocaprolactam | en |
dc.subject | peroxidation | en |
dc.title | Synthesis, characterization and biological studies of new antimony(III) halide complexes with ω-thiocaprolactam | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.jinorgbio.2012.01.014 | |
dc.description.volume | 109 | |
dc.description.startingpage | 57 | |
dc.description.endingpage | 65 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Manufacturers: Aldrich | en |
dc.description.notes | Cited By :24</p> | en |
dc.source.abbreviation | J.Inorg.Biochem. | en |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Hadjikakou, Sotiris K. [0000-0001-9556-6266] | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0001-9556-6266 | |