Randomness switches the dynamics in a biophysical model for Parkinson Disease
AuthorSpiliotis, K. G.
Georgiou, Georgios C.
SourceAIP Conference Proceedings
International Conference of Numerical Analysis and Applied Mathematics, ICNAAM 2012
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The interpallidal network of the two areas, the Globus Pallidus External (GPE) and the Subthalamic nucleus, (STN) plays an important role for controlling the movement. Changes in the dynamics of this network are closed related with the Parkinson Disease (PD) symptoms. In this paper we show how the connectivity between these two areas affects the dynamics of a biophysical-based neuronal-model. By changing the kind of interconnection from local (or lattice) to random structure between the two areas, the system switches the dynamics from correlated and clustered firing state (associated with PD) to a relatively quietness and less correlate state. In addition, the synchronization of the GPE and STN with respect to the connectivity distribution is examined by using the phase synchronization index. © 2012 American Institute of Physics.