Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Submit Date
Now showing items 21-40 of 40
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Master Thesis Open Access
Modelling Glioblastoma Angiogenesis in Drosophila larvae
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
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Master Thesis Open Access
Molecular mechanisms that Hepatitis B virus uses to induce Hepatocellular Carcinoma
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-07)Hepatitis B is an infectious liver disease caused by the Hepatitis B virus (HBV). HBV is a small DNA virus that mainly affects hepatocytes, which are the main liver cells, and it has the ability to replicate by reverse ...
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Master Thesis Open Access
Recombinant Poliovirus a therapeutic agent for Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05)Cancer is a leading cause of global mortality, and its burden is growing despite the availability of standard treatment methods. Genetically and Morphologically tumor cells differ from normal cells. However, cancers arise ...
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Master Thesis Open Access
Hypomethylation of Alu Elements in chronic lymphocytic leukemia
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...
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Master Thesis Open Access
The PINK1/Parkin-dependent mitophagy pathway and its role in Parkinson’s disease
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)Parkinson's disease is the second most prevalent neurodegenerative disease, surpassed only by Alzheimer’s disease. The disease is relentless, progressive, and incurable, and there is a great need to understand its causes ...
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Master Thesis Open Access
MicroRNAs in Alzheimer's Disease: A Comprehensive Analysis and Therapeutic Implications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)Alzheimer's disease (AD) remains an enigmatic challenge in the field of neurodegenerative disorders, characterized by progressive cognitive decline and the accumulation of aberrant protein aggregates in the brain. This ...
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Master Thesis Open Access
Novel therapeutic approaches targeting the molecular mechanisms governing SARS-CoV-2 infection
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing worldwide pandemic of Coronavirus Disease 2019 (COVID-19), which remains a public health concern despite the successful ...
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Master Thesis Open Access
Application of conservation genetics in conservation planning, with a special focus on the impacts of hybridization on birds and their conservation
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-06-01)Biodiversity consists of all different live forms found in Earth. It is important to sustain it as it has several important aspects, such as maintaining ecosystems, helping with their proper functioning and it also plays ...
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Master Thesis Open Access
Mechanisms underlying Trastuzumab Resistance in HER2-positive (HER2+) Breast Cancer and potential therapeutic approaches
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)HER2-positive (HER2+) breast cancer is characterized by overexpression of HER2 (Human Epidermal Growth Factor Receptor 2) protein on the surface of cells in the breast's ducts or lobes. HER2 overexpression creates an ...
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Master Thesis Open Access
EZH2: Role in breast cancer and potential therapeutic applications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)Human diseases, most notably cancer, are frequently associated with epigenetic dysregulation. Epigenetic modifications control gene function beyond the underlying sequence and are heritable but reversible alterations in ...
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Master Thesis Open Access
Prostate Cancer Organoids in the Fight Against Prostate Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)Ο καρκίνος του προστάτη είναι μία από τις κυριότερες ασθένειες που αυξάνουν τα ποσοστά νοσηρότητας και θνησιμότητας στους άνδρες παγκοσμίως. Παρά τη µεγάλη ετερογένεια µεταξύ των όγκων και των ασθενών, ο καρκίνος του ...
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Master Thesis Open Access
Genetic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF91_cpx) and Identification of Three Additional Putative CRFs: Increased Prevalence of URFs and CRFs in the Polyphyletic HIV-1 Infection in Cyprus.
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-27)HIV is characterized by a high degree of genetic variation, as it is evident from numerous genetically distinct subtypes (within the major group M) and circulating recombinant forms (CRFs). The genetic diversity of HIV is ...
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Master Thesis Open Access
Adherens Junctions spatially guide ECM deposition by stimulating integrin activation and clustering
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)The extracellular matrix (ECM) plays an essential role in all multicellular organisms as a substrate for cell anchorage and tissue scaffolding. It is involved in diverse processes such as cell proliferation and survival, ...
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Master Thesis Open Access
Detection of SARS-CoV-2 in Clinical Samples Using Mismatch-Tolerant Molecular Beacons and Real-Time RT-PCR
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-14)Infectious diseases that arise from pathogens are considered as a major threat towards global public health. Most recently, the novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome ...
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Master Thesis
Stumps and Lipin in the Drosophila midgut enteroendocrine cells independently regulate intestinal regeneration and permeability
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05)Leaky Gut Syndrome is a condition characterised by increased intestinal permeability that may lead to increased flow of lumen contents, such as nutrients, biomolecules, toxins, microbes, and chemicals, into the ...
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Master Thesis Open Access
Common Myna (Acridotheres tristis) in Cyprus: mapping spread, control methods and impacts on birds globally.
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05-20)The Common Myna (Acridotheres tristis) stands as one of the most important avian invaders on a global scale, its presence extending across diverse ecosystems and continents. With its range continually expanding, the Common ...
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Master Thesis Open Access
“Evaluation of the deep root training tube system’s performance under different drought stress conditions for 13 native plant species to Cyprus.
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)Climate change and desertification significantly threaten the Eastern Mediterranean, especially Cyprus. The island is experiencing a rise in average temperature and a significant decrease in the percentage of annual average ...
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Master Thesis Open Access
InvasiCell is a physiologically relevant in vitro model for the study of tumor progression and the evaluation of potential cancer medications more accurately than current in vitro assays
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05)Cancer cases have been constantly increasing over the past few decades, leading it to become the second cause of lethality worldwide, with cancer metastasis being responsible for approximately 90% of cancer-related deaths. ...
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Master Thesis Open Access
The effect of beneficial microbes and attapulgite on growth and productivity of Lavandula angustifolia and Thymus vulgaris under drought stress
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05-27)Climate change and desertification have become topics of broad interest, as their consequences are currently being experienced, and future projections investigate their prolonged effects. Desertification is primarily ...
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Master Thesis Open Access
Comparative phylogeography of sand-dwelling beetles along the coastline of the Republic of Cyprus
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-12-18)Coastal sand dunes are fragile and dynamic habitats affected by significant anthropogenic pressures. While many specialised and non-specialised organisms inhabit sand dunes, most have yet to be studied in Cyprus. This ...