Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title
Now showing items 5-24 of 28
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Master Thesis Open Access
Detection of SARS-CoV-2 in Clinical Samples Using Mismatch-Tolerant Molecular Beacons and Real-Time RT-PCR
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-14)Infectious diseases that arise from pathogens are considered as a major threat towards global public health. Most recently, the novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome ...
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Master Thesis
Development of a de novo Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection and Discrimination of SARS-CoV-2 Variants of Concern
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-16)The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and is the causative agent of the Coronavirus Disease 2019 (COVID-19). Since its emergence it has led to a global pandemic with devastating ...
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Master Thesis
Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40
(2023-05-24)NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...
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Master Thesis Open Access
Extracellular Regulated Kinase (ERK): A novel regulator in the development and function of cilia
(2023-06-14)The role of cilia in biomedicine is becoming more and more recognized since defects in ciliary structure and function induce ciliopathies such as cystic kidney disease, neurological anomalies, obesity, blindness, and ...
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Master Thesis Open Access
Gene therapies and their potential application in Type 1 Diabetes
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-14)Type 1 diabetes (T1D) is an autoimmune metabolic disorder, that arises due to autoimmune destruction of the β-cells in the islets of Langerhans in the pancreas. As a result, there is insufficient insulin production and ...
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Master Thesis Open Access
The genetic basis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in two Cypriot Families and the development of a robust PKD1 and PKD2 mutation screening test using amplicon-based Next-Generation Sequencing (NGS)
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-06-11)Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney diseases, with a frequency of 1 in 1000 people in the general population. This progressive disorder is mainly caused by ...
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Master Thesis Open Access
Genetic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF91_cpx) and Identification of Three Additional Putative CRFs: Increased Prevalence of URFs and CRFs in the Polyphyletic HIV-1 Infection in Cyprus.
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-27)HIV is characterized by a high degree of genetic variation, as it is evident from numerous genetically distinct subtypes (within the major group M) and circulating recombinant forms (CRFs). The genetic diversity of HIV is ...
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Master Thesis Open Access
The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers
(2023-05-18)Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...
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Master Thesis Open Access
Human immune responses upon SARS-CoV-2 infection- inflammation and cytokine storm
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in December 2019 in the city of Wuhan, China, causing the COVID-19 pandemic of acute respiratory ...
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Master Thesis Open Access
Hypomethylation of Alu Elements in chronic lymphocytic leukemia
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...
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Master Thesis Open Access
Inhibition of Focal Adhesion Kinase as an anti-metastatic therapy
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-07)Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has a physiological role in cell migration, cell survival, wound healing, and cell cycle progression, via both kinase-dependent and kinase-independent functions. ...
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Master Thesis Open Access
Investigating the role of Methyl CpG Binding proteins in Cervical Cancer
(2023-05-12)DNA methylation (5mC) is one of the main epigenetic modifications that drive gene regulation. Methyl CpG binding proteins (MBDs) bind methylated DNA and recruit the nucleosome remodelling and deacetylase complex (Nurd) ...
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Master Thesis
Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response
(2023-05-28)N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...
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Master Thesis Open Access
Investigation of the role of cytoskeleton protein KATNAL2 in ribosomal gene transcription in mouse cells
(2023-05-23)The discovery that katanin-like cytoskeleton protein KATNAL2, in addition to its intracellular localization at MTs and sites associated with MTs (centrioles, cilia), also, unexpectedly, resides in the nucleolus, suggests ...
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Master Thesis Open Access
Mechanical Cell Membrane stimulation using Magnetic Tweezers increases cell membrane stiffness through integrin dependent and independent mechanisms
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)Several cellular processes, such as proliferation, migration tissue morphogenesis and tissue regeneration, are closely regulated by the cells ability to sense their microenvironment and translate mechanical stimuli to ...
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Master Thesis Open Access
Modelling Glioblastoma Angiogenesis in Drosophila larvae
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
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Master Thesis Open Access
Molecular mechanisms that Hepatitis B virus uses to induce Hepatocellular Carcinoma
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-07)Hepatitis B is an infectious liver disease caused by the Hepatitis B virus (HBV). HBV is a small DNA virus that mainly affects hepatocytes, which are the main liver cells, and it has the ability to replicate by reverse ...
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Master Thesis Open Access
Molecular pathways affected by HBx protein and their targeting for therapy of Hepatocellular carcinoma
(2022-12-09)Hepatitis B virus (HBV) infection can cause several types of liver disease including acute hepatitis, chronic hepatitis, and liver cirrhosis. It is also considered a significant risk factor for Hepatocellular carcinoma ...
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Master Thesis Open Access
The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...
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Master Thesis Open Access
Novel molecular approaches to treat colorectal cancer
(2021-12-10)Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...