Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title

Now showing items 14-33 of 40

    • Master Thesis  Open Access

      Gene therapies and their potential application in Type 1 Diabetes 

      Kyriakou, Mikaella K. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-14)
      Type 1 diabetes (T1D) is an autoimmune metabolic disorder, that arises due to autoimmune destruction of the β-cells in the islets of Langerhans in the pancreas. As a result, there is insufficient insulin production and ...
    • Master Thesis  Open Access

      The genetic basis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in two Cypriot Families and the development of a robust PKD1 and PKD2 mutation screening test using amplicon-based Next-Generation Sequencing (NGS) 

      Petrou, Avgousta (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-06-11)
      Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney diseases, with a frequency of 1 in 1000 people in the general population. This progressive disorder is mainly caused by ...
    • Master Thesis  Open Access

      Genetic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF91_cpx) and Identification of Three Additional Putative CRFs: Increased Prevalence of URFs and CRFs in the Polyphyletic HIV-1 Infection in Cyprus. 

      Georgiou, Vasilis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-27)
      HIV is characterized by a high degree of genetic variation, as it is evident from numerous genetically distinct subtypes (within the major group M) and circulating recombinant forms (CRFs). The genetic diversity of HIV is ...
    • Master Thesis  Open Access

      The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers 

      Andreou, Vasiliki (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-18)
      Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...
    • Master Thesis  Open Access

      Human immune responses upon SARS-CoV-2 infection- inflammation and cytokine storm 

      Syrimi, Andriani (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)
      Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in December 2019 in the city of Wuhan, China, causing the COVID-19 pandemic of acute respiratory ...
    • Master Thesis  Open Access

      Hypomethylation of Alu Elements in chronic lymphocytic leukemia 

      Prodromou, Marios (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)
      CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...
    • Master Thesis  Open Access

      Inhibition of Focal Adhesion Kinase as an anti-metastatic therapy 

      Dionysi, Eleni N. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-07)
      Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has a physiological role in cell migration, cell survival, wound healing, and cell cycle progression, via both kinase-dependent and kinase-independent functions. ...
    • Master Thesis  Open Access

      InvasiCell is a physiologically relevant in vitro model for the study of tumor progression and the evaluation of potential cancer medications more accurately than current in vitro assays 

      Manoli, Alexandra (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05)
      Cancer cases have been constantly increasing over the past few decades, leading it to become the second cause of lethality worldwide, with cancer metastasis being responsible for approximately 90% of cancer-related deaths. ...
    • Master Thesis  Open Access

      Investigating the role of Methyl CpG Binding proteins in Cervical Cancer 

      Patera, Eleftherios (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-12)
      DNA methylation (5mC) is one of the main epigenetic modifications that drive gene regulation. Methyl CpG binding proteins (MBDs) bind methylated DNA and recruit the nucleosome remodelling and deacetylase complex (Nurd) ...
    • Master Thesis  

      Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response 

      Papa, Christina C. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-28)
      N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...
    • Master Thesis  Open Access

      Investigation of the role of cytoskeleton protein KATNAL2 in ribosomal gene transcription in mouse cells 

      Timotheou, Kyriaki M (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-23)
      The discovery that katanin-like cytoskeleton protein KATNAL2, in addition to its intracellular localization at MTs and sites associated with MTs (centrioles, cilia), also, unexpectedly, resides in the nucleolus, suggests ...
    • Master Thesis  Open Access

      Mechanical Cell Membrane stimulation using Magnetic Tweezers increases cell membrane stiffness through integrin dependent and independent mechanisms 

      Michanikou, Antonis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)
      Several cellular processes, such as proliferation, migration tissue morphogenesis and tissue regeneration, are closely regulated by the cells ability to sense their microenvironment and translate mechanical stimuli to ...
    • Master Thesis  Open Access

      Mechanisms underlying Trastuzumab Resistance in HER2-positive (HER2+) Breast Cancer and potential therapeutic approaches 

      Theodorou, Troodia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
      HER2-positive (HER2+) breast cancer is characterized by overexpression of HER2 (Human Epidermal Growth Factor Receptor 2) protein on the surface of cells in the breast's ducts or lobes. HER2 overexpression creates an ...
    • Master Thesis  Open Access

      MicroRNAs in Alzheimer's Disease: A Comprehensive Analysis and Therapeutic Implications 

      Lazaridou, Antrea (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
      Alzheimer's disease (AD) remains an enigmatic challenge in the field of neurodegenerative disorders, characterized by progressive cognitive decline and the accumulation of aberrant protein aggregates in the brain. This ...
    • Master Thesis  Open Access

      Modelling Glioblastoma Angiogenesis in Drosophila larvae 

      Konstantinou, Anna G. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
      Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
    • Master Thesis  Open Access

      Molecular mechanisms that Hepatitis B virus uses to induce Hepatocellular Carcinoma 

      Frangou, Antrea (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-07)
      Hepatitis B is an infectious liver disease caused by the Hepatitis B virus (HBV). HBV is a small DNA virus that mainly affects hepatocytes, which are the main liver cells, and it has the ability to replicate by reverse ...
    • Master Thesis  Open Access

      Molecular pathways affected by HBx protein and their targeting for therapy of Hepatocellular carcinoma 

      Ketti, Stavriani A. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-09)
      Hepatitis B virus (HBV) infection can cause several types of liver disease including acute hepatitis, chronic hepatitis, and liver cirrhosis. It is also considered a significant risk factor for Hepatocellular carcinoma ...
    • Master Thesis  Open Access

      The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation 

      Alshikh Saleh, Ahmad (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)
      Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...
    • Master Thesis  Open Access

      Novel molecular approaches to treat colorectal cancer 

      Argyrou, Christina (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)
      Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...
    • Master Thesis  Open Access

      Novel therapeutic approaches targeting the molecular mechanisms governing SARS-CoV-2 infection 

      Chasikos, Ioannis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023)
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing worldwide pandemic of Coronavirus Disease 2019 (COVID-19), which remains a public health concern despite the successful ...