Synthesis, characterization and cytotoxic properties of bismuth(III) chloride complexes with heterocyclic thioamides
Date
2018Author
Yarar, S.Ozturk, I. I.
Banti, C. N.
Panagiotou, N.
Papatriantafyllopoulou, C.
Manoli, M.
Manos, M. J.
Tasiopoulos, Anastasios J.
Hadjikakou, S. K.
ISSN
0020-1693Source
Inorganica Chimica ActaVolume
471Pages
23-33Google Scholar check
Metadata
Show full item recordAbstract
Bismuth(III) complexes of the formulae [BiCl3(MBZT)2] ·H2O} (1), {[BiCl2(µ2-Cl)(MMI)2]2·(CH3)2CO} (2), {[BiCl3(µ2-S-PYT)(PYT)]2} (3) {([BiCl2(MBZIM)4]+)·2(Cl-)·(H3O+) ·2H2O} (4) and [BiCl3(tHPMT)3] (5) (where MBZT: 2-mercaptobenzothiazole, MMI: 2-mercapto-1-methylimidazole, PYT: 2-mercaptopyridine, MBZIM: 2-mercaptobenzimidazole, tHPMT: 2-mercapto-3,4,5,6-tetrahydro-pyrimidine) are reported. The compounds were characterized by spectroscopic techniques including FT-IR, FT-Raman, UV-Vis, 1H-,13C-NMR spectroscopies, TG-DTA, e.a, molar conductivity and by single-crystal X-ray diffraction analysis. While 1, 4 and 5 are mononuclear compounds, 2 and 3 are dinuclear complexes in which the two Bi3+ ions are bridged through Cl- and SR groups respectively. Interestingly, 3 is the first example of dinuclear Bi3+ complex containing two Bi-(μ-SR)-Bi bridges between the two metal centers formed by covalent bonds. Compounds 1–5 were evaluated for their in vitro cytotoxic activity against human adenocarcinoma cervix (HeLa) and breast (MCF-7) cells. The toxicity of 1–5 was evaluated on normal human fetal lung fibroblast cells (MRC-5). The influence of 1–5, on the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX) was determined experimentally.