dc.contributor.author | Pal, Suchetan | en |
dc.contributor.author | Ray, Angana | en |
dc.contributor.author | Andreou, Chrysafis | en |
dc.contributor.author | Zhou, Yadong | en |
dc.contributor.author | Rakshit, Tatini | en |
dc.contributor.author | Wlodarczyk, Marek | en |
dc.contributor.author | Maeda, Masatomo | en |
dc.contributor.author | Toledo-Crow, Ricardo | en |
dc.contributor.author | Berisha, Naxhije | en |
dc.contributor.author | Yang, Jiang | en |
dc.contributor.author | Hsu, Hsiao-Ting | en |
dc.contributor.author | Oseledchyk, Anton | en |
dc.contributor.author | Mondal, Jagannath | en |
dc.contributor.author | Zou, Shengli | en |
dc.contributor.author | Kircher, Moritz F. | en |
dc.creator | Pal, Suchetan | en |
dc.creator | Ray, Angana | en |
dc.creator | Andreou, Chrysafis | en |
dc.creator | Zhou, Yadong | en |
dc.creator | Rakshit, Tatini | en |
dc.creator | Wlodarczyk, Marek | en |
dc.creator | Maeda, Masatomo | en |
dc.creator | Toledo-Crow, Ricardo | en |
dc.creator | Berisha, Naxhije | en |
dc.creator | Yang, Jiang | en |
dc.creator | Hsu, Hsiao-Ting | en |
dc.creator | Oseledchyk, Anton | en |
dc.creator | Mondal, Jagannath | en |
dc.creator | Zou, Shengli | en |
dc.creator | Kircher, Moritz F. | en |
dc.date.accessioned | 2021-01-26T09:45:47Z | |
dc.date.available | 2021-01-26T09:45:47Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/63397 | |
dc.description.abstract | Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cover a clinically relevant area in real-time. Herein, we report the rational design and optimization of fluorescence-Raman bimodal nanoparticles (FRNPs) that synergistically combine the specificity of Raman spectroscopy with the versatility and speed of fluorescence imaging. DNA-enabled molecular engineering allows the rational design of FRNPs with a detection limit as low as 5 × 10−15 M. FRNPs selectively accumulate in tumor tissue mouse cancer models and enable real-time fluorescence imaging for tumor detection, resection, and subsequent Raman-based verification of clean margins. Furthermore, FRNPs enable highly efficient image-guided photothermal ablation of tumors, widening the scope of the NPs into the therapeutic realm. | en |
dc.language.iso | en | en |
dc.source | Nature Communications | en |
dc.source.uri | https://www.nature.com/articles/s41467-019-09173-2 | |
dc.title | DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/s41467-019-09173-2 | |
dc.description.volume | 10 | |
dc.description.issue | 1 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών / Department of Electrical and Computer Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Andreou, Chrysafis [0000-0002-3464-9110] | |
dc.gnosis.orcid | 0000-0002-3464-9110 | |