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dc.contributor.authorPal, Suchetanen
dc.contributor.authorRay, Anganaen
dc.contributor.authorAndreou, Chrysafisen
dc.contributor.authorZhou, Yadongen
dc.contributor.authorRakshit, Tatinien
dc.contributor.authorWlodarczyk, Mareken
dc.contributor.authorMaeda, Masatomoen
dc.contributor.authorToledo-Crow, Ricardoen
dc.contributor.authorBerisha, Naxhijeen
dc.contributor.authorYang, Jiangen
dc.contributor.authorHsu, Hsiao-Tingen
dc.contributor.authorOseledchyk, Antonen
dc.contributor.authorMondal, Jagannathen
dc.contributor.authorZou, Shenglien
dc.contributor.authorKircher, Moritz F.en
dc.creatorPal, Suchetanen
dc.creatorRay, Anganaen
dc.creatorAndreou, Chrysafisen
dc.creatorZhou, Yadongen
dc.creatorRakshit, Tatinien
dc.creatorWlodarczyk, Mareken
dc.creatorMaeda, Masatomoen
dc.creatorToledo-Crow, Ricardoen
dc.creatorBerisha, Naxhijeen
dc.creatorYang, Jiangen
dc.creatorHsu, Hsiao-Tingen
dc.creatorOseledchyk, Antonen
dc.creatorMondal, Jagannathen
dc.creatorZou, Shenglien
dc.creatorKircher, Moritz F.en
dc.description.abstractRecently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cover a clinically relevant area in real-time. Herein, we report the rational design and optimization of fluorescence-Raman bimodal nanoparticles (FRNPs) that synergistically combine the specificity of Raman spectroscopy with the versatility and speed of fluorescence imaging. DNA-enabled molecular engineering allows the rational design of FRNPs with a detection limit as low as 5 × 10−15 M. FRNPs selectively accumulate in tumor tissue mouse cancer models and enable real-time fluorescence imaging for tumor detection, resection, and subsequent Raman-based verification of clean margins. Furthermore, FRNPs enable highly efficient image-guided photothermal ablation of tumors, widening the scope of the NPs into the therapeutic realm.en
dc.sourceNature Communicationsen
dc.titleDNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapyen
dc.description.issue1Πολυτεχνική Σχολή / Faculty of EngineeringΤμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών / Department of Electrical and Computer Engineering
dc.contributor.orcidAndreou, Chrysafis [0000-0002-3464-9110]

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