The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma
Ημερομηνία
2019Συγγραφέας
Constantinidou, AnastasiaTong, Daniel
Engelmann, Bodil
Chamberlain, Florence
Thway, Khin
Fisher, Cyril
Hayes, Andrew
Fotiadis, Nicos
Messiou, Christina
Miah, Aisha B.
Zaidi, Shane H.
Benson, Charlotte
Graaf, Winette Van Der
Jones, Robin L.
ISSN
0250-70051791-7530
Source
Anticancer ResearchVolume
39Issue
9Pages
4891-4896Google Scholar check
Metadata
Εμφάνιση πλήρους εγγραφήςΕπιτομή
Background/Aim: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease. Patients and Methods: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted. Results: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment. Conclusion: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.