Cost-effectiveness analysis of three algorithms for diagnosing primary ciliary dyskinesia: a simulation study
Papatheodorou, Stefania I.
Cohen, Joshua T.
Evans, John S.
Yiallouros, Panayiotis K.
SourceOrphanet Journal of Rare Diseases
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Primary Ciliary Dyskinesia (PCD) diagnosis relies on a combination of tests which may include (a) nasal Nitric Oxide (nNO), (b) High Speed Video Microscopy (HSVM) and (c) Transmission Electron Microscopy (TEM). There is variability in the availability of these tests and lack of universal agreement whether diagnostic tests should be performed in sequence or in parallel. We assessed three combinations of tests for PCD diagnosis and estimated net sensitivity and specificity as well as cost-effectiveness (CE) and incremental cost-effectiveness (ICE) ratios.