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dc.contributor.authorYiallouros, Panayiotisen
dc.contributor.otherLucas, Jane S.en
dc.contributor.otherGahleitner, Florianen
dc.contributor.otherAmorim, Adelinaen
dc.contributor.otherBoon, Miekeen
dc.contributor.otherBrown, Philippaen
dc.contributor.otherConstant, Carolinaen
dc.contributor.otherCook, Simonen
dc.contributor.otherCrowley, Suzanneen
dc.contributor.otherDestouches, Damien M. S.en
dc.contributor.otherEber, Ernsten
dc.contributor.otherMussaffi, Hudaen
dc.contributor.otherHaarman, Ericen
dc.contributor.otherHarris, Amandaen
dc.contributor.otherKoerner-Rettberg, Cordulaen
dc.contributor.otherKuehni, Claudia E.en
dc.contributor.otherLatzin, Philippen
dc.contributor.otherLoebinger, Michael R.en
dc.contributor.otherLorent, Natalieen
dc.contributor.otherMaitre, Bernarden
dc.contributor.otherMoreno-Galdó, Antonioen
dc.contributor.otherNielsen, Kim G.en
dc.contributor.otherÖzçelik, Uğuren
dc.contributor.otherPhilipsen, Lue Katrine Drasbæken
dc.contributor.otherPohunek, Petren
dc.contributor.otherPolverino, Evaen
dc.contributor.otherRademacher, Jessicaen
dc.contributor.otherRobinson, Philen
dc.contributor.otherSnijders, Deborahen
dc.contributor.otherCarr, Siobhán B.en
dc.creatorYiallouros, Panayiotisen
dc.description.abstractPulmonary exacerbations are a cause of significant morbidity in patients with primary ciliary dyskinesia (PCD) and are frequently used as an outcome measure in clinical research into chronic lung diseases. So far, there has been no consensus on the definition of pulmonary exacerbations in PCD. 30 multidisciplinary experts and patients developed a consensus definition for children and adults with PCD. Following a systematic review, the panel used a modified Delphi process with a combination of face-to-face meetings and e-surveys to develop a definition that can be used in research settings for children and adults with PCD. A pulmonary exacerbation was defined by the presence of three or more of the following seven items: 1) increased cough, 2) change in sputum volume and/or colour, 3) increased shortness of breath perceived by the patient or parent, 4) decision to start or change antibiotic treatment because of perceived pulmonary symptoms, 5) malaise, tiredness, fatigue or lethargy, 6) new or increased haemoptysis, and 7) temperature >38°C. The consensus panel proposed that the definition should be used for future clinical trials. The definition should be validated and the usability assessed during these studies. Tweetable abstract @ERSpublications click to tweetA consensus definition for pulmonary exacerbations in children and adults with PCD for use in clinical trials
dc.sourceERJ Open Researchen
dc.titlePulmonary exacerbations in patients with primary ciliary dyskinesia: an expert consensus definition for use in clinical trialsen
dc.description.issue1Ιατρική Σχολή / Medical SchoolΙατρική Σχολή / Medical School
dc.contributor.orcidYiallouros, Panayiotis [0000-0002-8339-9285]
dc.contributor.orcidLatzin, Philipp [0000-0002-5239-1571]
dc.contributor.orcidKuehni, Claudia E. [0000-0001-8957-2002]

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