dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Kostaki, Evangelia-Georgia | en |
dc.contributor.author | Frampton, Daniel | en |
dc.contributor.author | Paraskevis, Dimitrios | en |
dc.contributor.author | Pantavou, Katerina | en |
dc.contributor.author | Ferns, Bridget | en |
dc.contributor.author | Raffle, Jade | en |
dc.contributor.author | Grant, Paul | en |
dc.contributor.author | Kozlakidis, Zisis | en |
dc.contributor.author | Hadjikou, Andria | en |
dc.contributor.author | Pavlitina, Eirini | en |
dc.contributor.author | Williams, Leslie D. | en |
dc.contributor.author | Hatzakis, Angelos | en |
dc.contributor.author | Friedman, Samuel R. | en |
dc.contributor.author | Nastouli, Eleni | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Kostaki, Evangelia-Georgia | en |
dc.creator | Frampton, Daniel | en |
dc.creator | Paraskevis, Dimitrios | en |
dc.creator | Pantavou, Katerina | en |
dc.creator | Ferns, Bridget | en |
dc.creator | Raffle, Jade | en |
dc.creator | Grant, Paul | en |
dc.creator | Kozlakidis, Zisis | en |
dc.creator | Hadjikou, Andria | en |
dc.creator | Pavlitina, Eirini | en |
dc.creator | Williams, Leslie D. | en |
dc.creator | Hatzakis, Angelos | en |
dc.creator | Friedman, Samuel R. | en |
dc.creator | Nastouli, Eleni | en |
dc.date.accessioned | 2021-02-23T14:38:23Z | |
dc.date.available | 2021-02-23T14:38:23Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1873-4251 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64083 | |
dc.description.abstract | BACKGROUND: TRIP (Transmission Reduction Intervention Project) was a network-based, contact tracing approach to locate and link to care, mostly people who inject drugs (PWID) with recent HIV infection. OBJECTIVE: We investigated whether sequences from HIV-infected participants with high viral load cluster together more frequently than what is expected by chance. METHODS: Paired end reads were generated for 104 samples using Illumina MiSeq next-generation sequencing. RESULTS: 63 sequences belonged to previously identified local transmission networks of PWID (LTNs) of an HIV outbreak in Athens, Greece. For two HIV-RNA cut-offs (105 and 106 IU/mL), HIV transmissions were more likely between PWID with similar levels of HIV-RNA (p<0.001). 10 of the 14 sequences (71.4%) from PWID with HIV-RNA >106 IU/mL were clustered in 5 pairs. For 4 of these clusters (80%), there was in each one of them at least one sequence from a recently HIVinfected PWID. CONCLUSION: We showed that transmissions are more likely among PWID with high viremia. | en |
dc.language.iso | eng | en |
dc.source | Current HIV research | en |
dc.source.uri | http://www.ncbi.nlm.nih.gov/pubmed/30706819 | |
dc.title | Near Full-length Genomic Sequencing and Molecular Analysis of HIV-Infected Individuals in a Network-based Intervention (TRIP) in Athens, Greece: Evidence that Transmissions Occur More Frequently from those with High HIV-RNA | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.2174/1570162X17666190130120757 | |
dc.description.volume | 16 | |
dc.description.issue | 5 | |
dc.description.startingpage | 345 | |
dc.description.endingpage | 353 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | Curr. HIV Res. | en |
dc.contributor.orcid | Nikolopoulos, Georgios K. [0000-0002-3307-0246] | |
dc.contributor.orcid | Pantavou, Katerina [0000-0002-9176-4369] | |
dc.contributor.orcid | Paraskevis, Dimitrios [0000-0001-6167-7152] | |
dc.contributor.orcid | Kostaki, Evangelia-Georgia [0000-0002-3346-0930] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0002-9176-4369 | |
dc.gnosis.orcid | 0000-0001-6167-7152|0000-0002-3346-0930 | |