dc.contributor.author | Jokinen, Jussi | en |
dc.contributor.author | Boström, Adrian E. | en |
dc.contributor.author | Dadfar, Ali | en |
dc.contributor.author | Ciuculete, Diana M. | en |
dc.contributor.author | Chatzittofis, Andreas | en |
dc.contributor.author | Åsberg, Marie | en |
dc.contributor.author | Schiöth, Helgi B. | en |
dc.creator | Jokinen, Jussi | en |
dc.creator | Boström, Adrian E. | en |
dc.creator | Dadfar, Ali | en |
dc.creator | Ciuculete, Diana M. | en |
dc.creator | Chatzittofis, Andreas | en |
dc.creator | Åsberg, Marie | en |
dc.creator | Schiöth, Helgi B. | en |
dc.date.accessioned | 2021-02-23T14:38:25Z | |
dc.date.available | 2021-02-23T14:38:25Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2352-3964 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64094 | |
dc.description.abstract | The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk score in two cohorts of adolescents (cohort 1 and 2). The genome-wide methylation pattern was measured in whole blood using the Illumina Infinium Methylation EPIC BeadChip. Subjects were stratified into high-risk and low-risk groups based on the severity of the suicidal behavior. We included CpG sites located within 2000 basepairs away from transcriptional start site of the following HPA-axis coupled genes: corticotropin releasing hormone (CRH), corticotropin releasing hormone binding protein (CRHBP), corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), FK506-binding protein 51 (FKBP5) and the glucocorticoid receptor (NR3C1). The methylation state of two corticotropin releasing hormone (CRH)-associated CpG sites were significantly hypomethylated in the high-risk group of suicide attempters (n=31) (cg19035496 and cg23409074) (p<0.001). Adolescent cohort 1 and 2 consisted of 129 and 93 subjects, respectively, and were stratified by the in silico generated DAWBA measurements of a general psychiatric risk score into high-risk group (>~50% risk) or controls. In adolescent cohort 2, cg19035496 was hypermethylated in subjects with a high general psychiatric risk score. Our results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents. | en |
dc.language.iso | eng | en |
dc.source | EBioMedicine | en |
dc.source.uri | http://www.ncbi.nlm.nih.gov/pubmed/29277323 | |
dc.title | Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.ebiom.2017.12.018 | |
dc.description.volume | 27 | |
dc.description.startingpage | 123 | |
dc.description.endingpage | 133 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | EBioMedicine | en |
dc.contributor.orcid | Chatzittofis, Andreas [0000-0002-6635-9564] | |
dc.gnosis.orcid | 0000-0002-6635-9564 | |