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dc.contributor.authorvon der Brelie, Christiande
dc.contributor.authorHadjigeorgiou, Georgiosen
dc.contributor.otherTsivgoulis, Georgiosen
dc.contributor.otherWilson, Duncanen
dc.contributor.otherKatsanos, Aristeidis H.en
dc.contributor.otherSargento-Freitas, Joãoen
dc.contributor.otherMarques-Matos, Cláudiaen
dc.contributor.otherAzevedo, Elsaen
dc.contributor.otherAdachi, Tomohideen
dc.contributor.otherAizawa, Yoshifusaen
dc.contributor.otherAbe, Hiroshien
dc.contributor.otherTomita, Hirofumien
dc.contributor.otherOkumura, Kenen
dc.contributor.otherHagii, Jojien
dc.contributor.otherSeiffge, David J.en
dc.contributor.otherLioutas, Vasileios-Arseniosen
dc.contributor.otherTraenka, Christopheren
dc.contributor.otherVarelas, Panayiotisen
dc.contributor.otherBasir, Ghazalaen
dc.contributor.otherKrogias, Christosen
dc.contributor.otherPurrucker, Jan C.en
dc.contributor.otherSharma, Vijay K.en
dc.contributor.otherRizos, Timolaosen
dc.contributor.otherMikulik, Roberten
dc.contributor.otherSobowale, Oluwaseun A.en
dc.contributor.otherBarlinn, Kristianen
dc.contributor.otherSallinen, Hanneen
dc.contributor.otherGoyal, Nitinen
dc.contributor.otherYeh, Shin-Joeen
dc.contributor.otherKarapanayiotides, Theodoreen
dc.contributor.otherWu, Teddy Y.en
dc.contributor.otherVadikolias, Konstantinosen
dc.contributor.otherFerrigno, Marcen
dc.contributor.otherHouben, Riken
dc.contributor.otherGiannopoulos, Sotiriosen
dc.contributor.otherSchreuder, Floris H. B. M.en
dc.contributor.otherChang, Jason J.en
dc.contributor.otherPerry, Luke A.en
dc.contributor.otherMehdorn, Maximilianen
dc.contributor.otherMarto, João-Pedroen
dc.contributor.otherPinho, Joãoen
dc.contributor.otherTanaka, Junen
dc.contributor.otherBoulanger, Marionen
dc.contributor.otherAl-Shahi Salman, Rustamen
dc.contributor.otherJäger, Hans R.en
dc.contributor.otherShakeshaft, Clareen
dc.contributor.otherYakushiji, Yusukeen
dc.contributor.otherChoi, Philip M. C.en
dc.contributor.otherStaals, Julieen
dc.contributor.otherCordonnier, Charlotteen
dc.contributor.otherJeng, Jiann-Shingen
dc.contributor.otherVeltkamp, Rolanden
dc.contributor.otherDowlatshahi, Daren
dc.contributor.otherEngelter, Stefan T.en
dc.contributor.otherParry-Jones, Adrian R.en
dc.contributor.otherMeretoja, Atteen
dc.contributor.otherMitsias, Panayiotis D.en
dc.contributor.otherAlexandrov, Andrei V.en
dc.contributor.otherAmbler, Garethen
dc.contributor.otherWerring, David J.en
dc.creatorvon der Brelie, Christiande
dc.creatorHadjigeorgiou, Georgiosen
dc.description.abstractOBJECTIVE: Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. METHODS: We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricular hemorrhage extension. RESULTS: We included 7 eligible studies comprising 219 NOAC-ICH and 831 VKA-ICH patients (mean age = 77 years, 52.5% females). The 30-day mortality was similar between NOAC-ICH and VKA-ICH (24.3% vs 26.5%en
dc.description.abstracthazard ratio = 0.94, 95% confidence interval [CI] = 0.67-1.31). However, in multivariate analyses adjusting for potential confounders, NOAC-ICH was associated with lower admission National Institutes of Health Stroke Scale (NIHSS) score (linear regression coefficient = -2.83, 95% CI = -5.28 to -0.38), lower likelihood of severe stroke (NIHSS > 10 points) on admission (odds ratio [OR] = 0.50, 95% CI = 0.30-0.84), and smaller baseline hematoma volume (linear regression coefficient = -0.24, 95% CI = -0.47 to -0.16). The two groups did not differ in the likelihood of baseline hematoma volume < 30cm3 (OR = 1.14, 95% CI = 0.81-1.62), hematoma expansion (OR = 0.97, 95% CI = 0.63-1.48), in-hospital mortality (OR = 0.73, 95% CI = 0.49-1.11), functional status at discharge (common OR = 0.78, 95% CI = 0.57-1.07), or functional status at 3 months (common OR = 1.03, 95% CI = 0.75-1.43). INTERPRETATION: Although functional outcome at discharge, 1 month, or 3 months was comparable after NOAC-ICH and VKA-ICH, patients with NOAC-ICH had smaller baseline hematoma volumes and less severe acute stroke syndromes. Ann Neurol 2018en
dc.sourceAnnals of Neurologyen
dc.titleNeuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhageen
dc.description.endingpage704Ιατρική Σχολή / Medical SchoolΙατρική Σχολή / Medical School
dc.source.abbreviationAnn. Neurol.en
dc.contributor.orcidHadjigeorgiou, Georgios [0000-0001-5386-4273]
dc.contributor.orcidTsivgoulis, Georgios [0000-0002-0640-3797]
dc.contributor.orcidKatsanos, Aristeidis H. [0000-0002-6359-0023]
dc.contributor.orcidKarapanayiotides, Theodore [0000-0002-2357-7967]

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