dc.contributor.author | von der Brelie, Christian | de |
dc.contributor.author | Hadjigeorgiou, Georgios | en |
dc.contributor.other | Tsivgoulis, Georgios | en |
dc.contributor.other | Wilson, Duncan | en |
dc.contributor.other | Katsanos, Aristeidis H. | en |
dc.contributor.other | Sargento-Freitas, João | en |
dc.contributor.other | Marques-Matos, Cláudia | en |
dc.contributor.other | Azevedo, Elsa | en |
dc.contributor.other | Adachi, Tomohide | en |
dc.contributor.other | Aizawa, Yoshifusa | en |
dc.contributor.other | Abe, Hiroshi | en |
dc.contributor.other | Tomita, Hirofumi | en |
dc.contributor.other | Okumura, Ken | en |
dc.contributor.other | Hagii, Joji | en |
dc.contributor.other | Seiffge, David J. | en |
dc.contributor.other | Lioutas, Vasileios-Arsenios | en |
dc.contributor.other | Traenka, Christopher | en |
dc.contributor.other | Varelas, Panayiotis | en |
dc.contributor.other | Basir, Ghazala | en |
dc.contributor.other | Krogias, Christos | en |
dc.contributor.other | Purrucker, Jan C. | en |
dc.contributor.other | Sharma, Vijay K. | en |
dc.contributor.other | Rizos, Timolaos | en |
dc.contributor.other | Mikulik, Robert | en |
dc.contributor.other | Sobowale, Oluwaseun A. | en |
dc.contributor.other | Barlinn, Kristian | en |
dc.contributor.other | Sallinen, Hanne | en |
dc.contributor.other | Goyal, Nitin | en |
dc.contributor.other | Yeh, Shin-Joe | en |
dc.contributor.other | Karapanayiotides, Theodore | en |
dc.contributor.other | Wu, Teddy Y. | en |
dc.contributor.other | Vadikolias, Konstantinos | en |
dc.contributor.other | Ferrigno, Marc | en |
dc.contributor.other | Houben, Rik | en |
dc.contributor.other | Giannopoulos, Sotirios | en |
dc.contributor.other | Schreuder, Floris H. B. M. | en |
dc.contributor.other | Chang, Jason J. | en |
dc.contributor.other | Perry, Luke A. | en |
dc.contributor.other | Mehdorn, Maximilian | en |
dc.contributor.other | Marto, João-Pedro | en |
dc.contributor.other | Pinho, João | en |
dc.contributor.other | Tanaka, Jun | en |
dc.contributor.other | Boulanger, Marion | en |
dc.contributor.other | Al-Shahi Salman, Rustam | en |
dc.contributor.other | Jäger, Hans R. | en |
dc.contributor.other | Shakeshaft, Clare | en |
dc.contributor.other | Yakushiji, Yusuke | en |
dc.contributor.other | Choi, Philip M. C. | en |
dc.contributor.other | Staals, Julie | en |
dc.contributor.other | Cordonnier, Charlotte | en |
dc.contributor.other | Jeng, Jiann-Shing | en |
dc.contributor.other | Veltkamp, Roland | en |
dc.contributor.other | Dowlatshahi, Dar | en |
dc.contributor.other | Engelter, Stefan T. | en |
dc.contributor.other | Parry-Jones, Adrian R. | en |
dc.contributor.other | Meretoja, Atte | en |
dc.contributor.other | Mitsias, Panayiotis D. | en |
dc.contributor.other | Alexandrov, Andrei V. | en |
dc.contributor.other | Ambler, Gareth | en |
dc.contributor.other | Werring, David J. | en |
dc.creator | von der Brelie, Christian | de |
dc.creator | Hadjigeorgiou, Georgios | en |
dc.date.accessioned | 2021-02-23T14:38:30Z | |
dc.date.available | 2021-02-23T14:38:30Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1531-8249 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64138 | |
dc.description.abstract | 84:702-712. | |
dc.description.abstract | OBJECTIVE: Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. METHODS: We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricular hemorrhage extension. RESULTS: We included 7 eligible studies comprising 219 NOAC-ICH and 831 VKA-ICH patients (mean age = 77 years, 52.5% females). The 30-day mortality was similar between NOAC-ICH and VKA-ICH (24.3% vs 26.5% | en |
dc.description.abstract | hazard ratio = 0.94, 95% confidence interval [CI] = 0.67-1.31). However, in multivariate analyses adjusting for potential confounders, NOAC-ICH was associated with lower admission National Institutes of Health Stroke Scale (NIHSS) score (linear regression coefficient = -2.83, 95% CI = -5.28 to -0.38), lower likelihood of severe stroke (NIHSS > 10 points) on admission (odds ratio [OR] = 0.50, 95% CI = 0.30-0.84), and smaller baseline hematoma volume (linear regression coefficient = -0.24, 95% CI = -0.47 to -0.16). The two groups did not differ in the likelihood of baseline hematoma volume < 30cm3 (OR = 1.14, 95% CI = 0.81-1.62), hematoma expansion (OR = 0.97, 95% CI = 0.63-1.48), in-hospital mortality (OR = 0.73, 95% CI = 0.49-1.11), functional status at discharge (common OR = 0.78, 95% CI = 0.57-1.07), or functional status at 3 months (common OR = 1.03, 95% CI = 0.75-1.43). INTERPRETATION: Although functional outcome at discharge, 1 month, or 3 months was comparable after NOAC-ICH and VKA-ICH, patients with NOAC-ICH had smaller baseline hematoma volumes and less severe acute stroke syndromes. Ann Neurol 2018 | en |
dc.language.iso | eng | en |
dc.source | Annals of Neurology | en |
dc.source.uri | http://www.ncbi.nlm.nih.gov/pubmed/30255970 | |
dc.title | Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/ana.25342 | |
dc.description.volume | 84 | |
dc.description.issue | 5 | |
dc.description.startingpage | 694 | |
dc.description.endingpage | 704 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | Ann. Neurol. | en |
dc.contributor.orcid | Hadjigeorgiou, Georgios [0000-0001-5386-4273] | |
dc.contributor.orcid | Tsivgoulis, Georgios [0000-0002-0640-3797] | |
dc.contributor.orcid | Katsanos, Aristeidis H. [0000-0002-6359-0023] | |
dc.contributor.orcid | Karapanayiotides, Theodore [0000-0002-2357-7967] | |
dc.gnosis.orcid | 0000-0001-5386-4273 | |
dc.gnosis.orcid | 0000-0002-0640-3797 | |
dc.gnosis.orcid | 0000-0002-6359-0023 | |
dc.gnosis.orcid | 0000-0002-2357-7967 | |