Show simple item record

dc.contributor.authorZis, Panagiotisen
dc.contributor.authorSarrigiannis, Ptolemaios Georgiosen
dc.contributor.authorRao, Dasappaiah Ganeshen
dc.contributor.authorSanders, David Surendranen
dc.contributor.authorHadjivassiliou, Mariosen
dc.creatorZis, Panagiotisen
dc.creatorSarrigiannis, Ptolemaios Georgiosen
dc.creatorRao, Dasappaiah Ganeshen
dc.creatorSanders, David Surendranen
dc.creatorHadjivassiliou, Mariosen
dc.date.accessioned2021-02-23T14:38:35Z
dc.date.available2021-02-23T14:38:35Z
dc.date.issued2019
dc.identifier.issn1941-9260
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/64172
dc.description.abstractObjectives: The commonest types of peripheral neuropathy in the context of Coeliac Disease (CD) and gluten sensitivity (GS) are length-dependent symmetrical sensorimotor neuropathies and sensory ganglionopathies. In patients with such neuropathy, (gluten neuropathy), peripheral neuropathic pain is prevalent suggesting involvement of small fibers. The purpose of this report was to describe the clinical characteristics of patients with CD or GS and pure small fiber neuropathy (SFN). Methods: We reviewed the records of all patients that had been referred to the Gluten-Related Neurological Disorders clinic who had clinical and neurophysiological evidence of SFN. All patients had serological evidence of gluten sensitivity (GS) prior to commencing GFD. All patients were offered a duodenum biopsy. Patients with comorbidities that could cause SFN were excluded. Results: We identified 13 patients (9 males) with SFN and gluten sensitivity. Of 11 patients who underwent duodenal biopsy 10 had evidence of enteropathy (CD). Mean age at onset of pain was 53.5 ± 11.4 years (range 34-72) and mean age of CD/GS diagnosis was 50.8 ± 10.4 years (range 34-68). In 8 patients (61.5%) pain was the presenting feature. Neurophysiological assessment suggested a length-dependent small fiber neuropathy in 11 patients, whereas in 2, a non-length dependent pattern was identifying suggesting that the predominant pathology lies in the dorsal root ganglia. Conclusion: SFN can be a presenting feature of CD and GS and, therefore, screening for CD and GS should be included in the diagnostic workup of patients with idiopathic SFN.en
dc.language.isoengen
dc.sourcePostgraduate Medicineen
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/31359810
dc.titleSmall fiber neuropathy in coeliac disease and gluten sensitivityen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1080/00325481.2019.1650609
dc.description.volume131
dc.description.issue7
dc.description.startingpage496
dc.description.endingpage500
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.source.abbreviationPostgrad Meden
dc.contributor.orcidZis, Panagiotis [0000-0001-8567-3092]
dc.contributor.orcidSarrigiannis, Ptolemaios Georgios [0000-0002-8380-8755]
dc.contributor.orcidHadjivassiliou, Marios [0000-0003-2542-8954]
dc.contributor.orcidRao, Dasappaiah Ganesh [0000-0002-6350-8536]
dc.gnosis.orcid0000-0001-8567-3092
dc.gnosis.orcid0000-0002-8380-8755
dc.gnosis.orcid0000-0003-2542-8954
dc.gnosis.orcid0000-0002-6350-8536


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record