dc.contributor.author | Hadjivassiliou, Marios | en |
dc.contributor.author | Grünewald, Richard A. | en |
dc.contributor.author | Sanders, David S. | en |
dc.contributor.author | Zis, Panagiotis | en |
dc.contributor.author | Croall, Iain | en |
dc.contributor.author | Shanmugarajah, Priya D. | en |
dc.contributor.author | Sarrigiannis, Ptolemaios G. | en |
dc.contributor.author | Trott, Nick | en |
dc.contributor.author | Wild, Graeme | en |
dc.contributor.author | Hoggard, Nigel | en |
dc.creator | Hadjivassiliou, Marios | en |
dc.creator | Grünewald, Richard A. | en |
dc.creator | Sanders, David S. | en |
dc.creator | Zis, Panagiotis | en |
dc.creator | Croall, Iain | en |
dc.creator | Shanmugarajah, Priya D. | en |
dc.creator | Sarrigiannis, Ptolemaios G. | en |
dc.creator | Trott, Nick | en |
dc.creator | Wild, Graeme | en |
dc.creator | Hoggard, Nigel | en |
dc.date.accessioned | 2021-02-23T14:38:37Z | |
dc.date.available | 2021-02-23T14:38:37Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64193 | |
dc.description.abstract | Background: Patients with gluten ataxia (GA) without enteropathy have lower levels of antigliadin antibodies (AGA) compared to patients with coeliac disease (CD). Magnetic Resonance Spectroscopy (NAA/Cr area ratio) of the cerebellum improves in patients with GA following a strict gluten-free diet (GFD). This is associated with clinical improvement. We present our experience of the effect of a GFD in patients with ataxia and low levels of AGA antibodies measured by a commercial assay. Methods: Consecutive patients with ataxia and serum AGA levels below the positive cut-off for CD but above a re-defined cut-off in the context of GA underwent MR spectroscopy at baseline and after a GFD. Results: Twenty-one consecutive patients with GA were included. Ten were on a strict GFD with elimination of AGA, 5 were on a GFD but continued to have AGA, and 6 patients did not go on a GFD. The NAA/Cr area ratio from the cerebellar vermis increased in all patients on a strict GFD, increased in only 1 out of 5 (20%) patients on a GFD with persisting circulating AGA, and decreased in all patients not on a GFD. Conclusion: Patients with ataxia and low titres of AGA benefit from a strict GFD. The results suggest an urgent need to redefine the serological cut-off for circulating AGA in diagnosing GA. | en |
dc.language.iso | en | en |
dc.source | Nutrients | en |
dc.source.uri | https://www.mdpi.com/2072-6643/10/10/1444 | |
dc.title | The Significance of Low Titre Antigliadin Antibodies in the Diagnosis of Gluten Ataxia | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.3390/nu10101444 | |
dc.description.volume | 10 | |
dc.description.issue | 10 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Zis, Panagiotis [0000-0001-8567-3092] | |
dc.contributor.orcid | Sarrigiannis, Ptolemaios G. [0000-0002-8380-8755] | |
dc.contributor.orcid | Hadjivassiliou, Marios [0000-0003-2542-8954] | |
dc.gnosis.orcid | 0000-0001-8567-3092 | |
dc.gnosis.orcid | 0000-0002-8380-8755 | |
dc.gnosis.orcid | 0000-0003-2542-8954 | |