Nocebo in chronic inflammatory demyelinating polyneuropathy
a systematic review and meta-analysis of placebo-controlled clinical trials
dc.contributor.author | Zis, Panagiotis | en |
dc.contributor.author | Hadjivassiliou, Marios | en |
dc.contributor.author | Sarrigiannis, Ptolemaios G. | en |
dc.contributor.author | Jenkins, Thomas M. | en |
dc.contributor.author | Mitsikostas, Dimos-Dimitrios | en |
dc.creator | Zis, Panagiotis | en |
dc.creator | Hadjivassiliou, Marios | en |
dc.creator | Sarrigiannis, Ptolemaios G. | en |
dc.creator | Jenkins, Thomas M. | en |
dc.creator | Mitsikostas, Dimos-Dimitrios | en |
dc.date.accessioned | 2021-02-23T14:38:39Z | |
dc.date.available | 2021-02-23T14:38:39Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1878-5883 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64211 | |
dc.description.abstract | INTRODUCTION: Nocebo is very prevalent among neurological disorders, resulting in low adherence and treatment outcome. We sought to examine the adverse events (AE) following placebo administration in placebo-controlled randomized clinical trials (RCTs) for chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: After a systematic literature search for RCTs for CIDP pharmacotherapy treatments, we assessed the number of AE in the placebo groups and the number discontinuations because of placebo intolerance. RESULTS: Our literature search strategy revealed 82 papers. Data were extracted from three RCTs fulfilling our inclusion criteria. Approximately two in five placebo-treated patients (42.0%) reported at least one AE and approximately one in fifty placebo-treated patients discontinued placebo treatment because of AEs (2.1%). All patients participating in the CIDP trials reported similar AEs independently of the study arm they belonged. CONCLUSION: Compared to other neurological diseases the nocebo effect in CIDP is significantly smaller. | en |
dc.language.iso | eng | en |
dc.source | Journal of the Neurological Sciences | en |
dc.source.uri | http://www.ncbi.nlm.nih.gov/pubmed/29627036 | |
dc.title | Nocebo in chronic inflammatory demyelinating polyneuropathy | en |
dc.title | a systematic review and meta-analysis of placebo-controlled clinical trials | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.jns.2018.03.009 | |
dc.description.volume | 388 | |
dc.description.startingpage | 79 | |
dc.description.endingpage | 83 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | J. Neurol. Sci. | en |
dc.contributor.orcid | Zis, Panagiotis [0000-0001-8567-3092] | |
dc.contributor.orcid | Sarrigiannis, Ptolemaios G. [0000-0002-8380-8755] | |
dc.contributor.orcid | Hadjivassiliou, Marios [0000-0003-2542-8954] | |
dc.contributor.orcid | Mitsikostas, Dimos-Dimitrios [0000-0002-4691-3388] | |
dc.gnosis.orcid | 0000-0001-8567-3092 | |
dc.gnosis.orcid | 0000-0002-8380-8755 | |
dc.gnosis.orcid | 0000-0003-2542-8954|0000-0002-4691-3388 |
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