The cortical focus in childhood absence epilepsy
evidence from nonlinear analysis of scalp EEG recordings
dc.contributor.author | Sarrigiannis, Ptolemaios G. | en |
dc.contributor.author | Zhao, Yifan | en |
dc.contributor.author | He, Fei | en |
dc.contributor.author | Billings, Stephen A. | en |
dc.contributor.author | Baster, Kathleen | en |
dc.contributor.author | Rittey, Chris | en |
dc.contributor.author | Yianni, John | en |
dc.contributor.author | Zis, Panagiotis | en |
dc.contributor.author | Wei, Hualiang | en |
dc.contributor.author | Hadjivassiliou, Marios | en |
dc.contributor.author | Grünewald, Richard | en |
dc.creator | Sarrigiannis, Ptolemaios G. | en |
dc.creator | Zhao, Yifan | en |
dc.creator | He, Fei | en |
dc.creator | Billings, Stephen A. | en |
dc.creator | Baster, Kathleen | en |
dc.creator | Rittey, Chris | en |
dc.creator | Yianni, John | en |
dc.creator | Zis, Panagiotis | en |
dc.creator | Wei, Hualiang | en |
dc.creator | Hadjivassiliou, Marios | en |
dc.creator | Grünewald, Richard | en |
dc.date.accessioned | 2021-02-23T14:38:40Z | |
dc.date.available | 2021-02-23T14:38:40Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1872-8952 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64213 | |
dc.description.abstract | OBJECTIVE: To determine the origin and dynamic characteristics of the generalised hyper-synchronous spike and wave (SW) discharges in childhood absence epilepsy (CAE). METHODS: We applied nonlinear methods, the error reduction ratio (ERR) causality test and cross-frequency analysis, with a nonlinear autoregressive exogenous (NARX) model, to electroencephalograms (EEGs) from CAE, selected with stringent electro-clinical criteria (17 cases, 42 absences). We analysed the pre-ictal and ictal strength of association between homologous and heterologous EEG derivations and estimated the direction of synchronisation and corresponding time lags. RESULTS: A frontal/fronto-central onset of the absences is detected in 13 of the 17 cases with the highest ictal strength of association between homologous frontal followed by centro-temporal and fronto-central areas. Delays consistently in excess of 4 ms occur at the very onset between these regions, swiftly followed by the emergence of "isochronous" (0-2 ms) synchronisation but dynamic time lag changes occur during SW discharges. CONCLUSIONS: In absences an initial cortico-cortical spread leads to dynamic lag changes to include periods of isochronous interhemispheric synchronisation, which we hypothesize is mediated by the thalamus. SIGNIFICANCE: Absences from CAE show ictal epileptic network dynamics remarkably similar to those observed in WAG/Rij rats which guided the formulation of the cortical focus theory. | en |
dc.language.iso | eng | en |
dc.source | Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology | en |
dc.source.uri | http://www.ncbi.nlm.nih.gov/pubmed/29414404 | |
dc.title | The cortical focus in childhood absence epilepsy | en |
dc.title | evidence from nonlinear analysis of scalp EEG recordings | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.clinph.2017.11.029 | |
dc.description.volume | 129 | |
dc.description.issue | 3 | |
dc.description.startingpage | 602 | |
dc.description.endingpage | 617 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | Clin Neurophysiol | en |
dc.contributor.orcid | Zis, Panagiotis [0000-0001-8567-3092] | |
dc.contributor.orcid | Sarrigiannis, Ptolemaios G. [0000-0002-8380-8755] | |
dc.contributor.orcid | Hadjivassiliou, Marios [0000-0003-2542-8954] | |
dc.gnosis.orcid | 0000-0001-8567-3092 | |
dc.gnosis.orcid | 0000-0002-8380-8755 | |
dc.gnosis.orcid | 0000-0003-2542-8954 |
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