dc.contributor.author | Usemann, Jakob | en |
dc.contributor.author | Xu, Binbin | en |
dc.contributor.author | Delgado-Eckert, Edgar | en |
dc.contributor.author | Korten, Insa | en |
dc.contributor.author | Anagnostopoulou, Pinelopi | en |
dc.contributor.author | Gorlanova, Olga | en |
dc.contributor.author | Kuehni, Claudia | en |
dc.contributor.author | Röösli, Martin | en |
dc.contributor.author | Latzin, Philipp | en |
dc.contributor.author | Frey, Urs | en |
dc.creator | Usemann, Jakob | en |
dc.creator | Xu, Binbin | en |
dc.creator | Delgado-Eckert, Edgar | en |
dc.creator | Korten, Insa | en |
dc.creator | Anagnostopoulou, Pinelopi | en |
dc.creator | Gorlanova, Olga | en |
dc.creator | Kuehni, Claudia | en |
dc.creator | Röösli, Martin | en |
dc.creator | Latzin, Philipp | en |
dc.creator | Frey, Urs | en |
dc.date.accessioned | 2021-02-23T14:38:41Z | |
dc.date.available | 2021-02-23T14:38:41Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2312-0541 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/64223 | |
dc.description.abstract | Children with frequent respiratory symptoms in infancy have an increased risk for later wheezing, but the association with symptom dynamics is unknown. We developed an observer-independent method to characterise symptom dynamics and tested their association with subsequent respiratory morbidity. In this birth-cohort of healthy neonates, we prospectively assessed weekly respiratory symptoms during infancy, resulting in a time series of 52 symptom scores. For each infant, we calculated the transition probability between two consecutive symptom scores. We used these transition probabilities to construct a Markov matrix, which characterised symptom dynamics quantitatively using an entropy parameter. Using this parameter, we determined phenotypes by hierarchical clustering. We then studied the association between phenotypes and wheezing at 6 years. In 322 children with complete data for symptom scores during infancy (16 864 observations), we identified three dynamic phenotypes. Compared to the low-risk phenotype, the high-risk phenotype, defined by the highest entropy parameter, was associated with an increased risk of wheezing (odds ratio (OR) 3.01, 95% CI 1.15–7.88) at 6 years. In this phenotype, infants were more often male (64%) and had been exposed to environmental tobacco smoke (31%). In addition, more infants had siblings (67%) and attended childcare (38%). We describe a novel method to objectively characterise dynamics of respiratory symptoms in infancy, which helps identify abnormal clinical susceptibility and recovery patterns of infant airways associated with persistent wheezing. Tweetable abstract @ERSpublications click to tweetUnsupervised analysis of symptom dynamics during infancy identifies subjects susceptible to persistent airway disease http://ow.ly/r9xz30lDpHB | en |
dc.language.iso | en | en |
dc.source | ERJ Open Research | en |
dc.source.uri | https://openres.ersjournals.com/content/4/4/00037-2018 | |
dc.title | Dynamics of respiratory symptoms during infancy and associations with wheezing at school age | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1183/23120541.00037-2018 | |
dc.description.volume | 4 | |
dc.description.issue | 4 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Anagnostopoulou, Pinelopi [0000-0003-2597-8016] | |
dc.contributor.orcid | Latzin, Philipp [0000-0002-5239-1571] | |
dc.contributor.orcid | Frey, Urs [0000-0003-3773-2822] | |
dc.gnosis.orcid | 0000-0003-2597-8016 | |
dc.gnosis.orcid | 0000-0002-5239-1571 | |
dc.gnosis.orcid | 0000-0003-3773-2822 | |